Effectiveness of omega-3 fatty acid supplementation in patients with Alzheimer disease: a systematic review and meta-analysis
Author
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Araya Quintanilla, F.
Author
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Gutiérrez Espinoza, H.
Author
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Sánchez Montoya, U.
Author
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Muñoz Yáñez, M. J.
Author
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Baeza Vergara, A.
Author
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Petersen Yanjarí, M. J.
Author
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Fernández Lecaros, L.
Admission date
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2020-04-22T23:15:32Z
Available date
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2020-04-22T23:15:32Z
Publication date
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2020
Cita de ítem
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Neurología. 2020: 35(2).105-144
es_ES
Identifier
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10.1016/j.nrt.2017.07.009
Identifier
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https://repositorio.uchile.cl/handle/2250/174038
Abstract
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ntroduction: Alzheimer disease (AD) is a neurodegenerative disease characterised by progressive dementia associated with global cognitive dysfunction.
Methods: We conducted a systematic review and meta-analysis of clinical trials evaluating omega-3 supplementation in patients with AD.
Objective: To determine if there is scientific evidence of the effectiveness of omega-3 supplementation in improving cognitive function in patients with AD.
Search strategy: We included only randomised controlled trials (RCTs) from the following databases: Medline, Cochrane Central, Cinahl, and LILACS. An electronic search was also conducted using Google Scholar.
Study selection: Six articles met the eligibility criteria. The risk of bias was assessed following the Cochrane method.
Conclusion: There is no consistent evidence to support the effectiveness of omega-3 supplementation in improving cognitive function in AD patients in the short and medium term.