Effects of preparation on catalytic, magnetic and hybrid micromotors on their functional features and application in gastric cancer biomarker detection
Author
dc.contributor.author
Báez Cornejo, Daniela
Author
dc.contributor.author
Ramos Peroni, Gabriel
Author
dc.contributor.author
Corvalán Aguilar, Alejandro
Author
dc.contributor.author
Cordero Garayar, María Luisa
Author
dc.contributor.author
Bollo Dragnic, Soledad
Author
dc.contributor.author
Kogan Bocian, Marcelo
Admission date
dc.date.accessioned
2020-05-13T22:21:23Z
Available date
dc.date.available
2020-05-13T22:21:23Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Sensors & Actuators: B. Chemical 310 (2020) 127843
es_ES
Identifier
dc.identifier.other
10.1016/j.snb.2020.127843
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/174706
Abstract
dc.description.abstract
Artificial micromotors evolve to improve multitasking performance in different research areas, and different power sources are combined to give rise to hybrid micromotors. Such combinations can alter physical features and influence movement aspects that until now have not been taken into account. Here, we comparatively studied how physical features of magnetic (erGO/Ni), catalytic (erGO/Pt), or dual propulsion (erGO/Pt-Ni and its inverted form erGO/Ni-Pt) micromotors can influence direction and speed. The results showed that erGO/Pt and erGO/Ni microtubes presented different growth modes dependent on experimental conditions. For the hybrid form, similar features were observed but thicker and shorter than their individual versions. The catalytic motion comparison demonstrated that the main movement pattern was circular, and erGO/Pt micromotors were faster than the hybrid form, reaching speeds up to 360 mu m s(-1). The addition of a third material decreased significantly the speed especially when nickel was in the last layer, demonstrating that the order in which metallic elements are deposited is relevant and influences the speed. The erGO/Pt microtubes were selected to detect Reprimo, a gastric cancer biomarker. The detection assay (static or catalytic conditions) relies on the turnoff/turn-on fluorescence recovery due to the hybridization process between the Reprimo probe tagged with a fluorescein amidine dye and target biomarker Reprimo ssDNA, followed by its detachment from microtube. The catalytic detection results have shown to possess great selectivity as well as good reproducibility and can become a promising strategy for qualitative or quantitative detection of Reprimo or other circulant cancer biomarkers based on DNA.
es_ES
Patrocinador
dc.description.sponsorship
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT
3170443
FONDEQUIP
EQM170111
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT
1170411
Beca de Doctorado Nacional (Conicyt, Chile)
21150648
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDAP
15130011
Effects of preparation on catalytic, magnetic and hybrid micromotors on their functional features and application in gastric cancer biomarker detection