Merkel cell polyomavirus detected in head and neck carcinomas from Chile
Author
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Muñoz, Juan P.
Author
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Blanco, Rancés
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Osorio, Julio C.
Author
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Estibaliz Oliva, Carolina
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Díaz, María José
Author
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Carrillo Beltrán, Diego
Author
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Aguayo, Rebeca
Author
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Castillo, Andrés
Author
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Tapia Pineda, Julio C.
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Calaf, Gloria M.
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Gaggero Brillouet, Aldo
Author
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Aguayo González, Francisco
Admission date
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2020-05-14T15:27:40Z
Available date
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2020-05-14T15:27:40Z
Publication date
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2020
Cita de ítem
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Infectious Agents and Cancer (2020) 15:4
es_ES
Identifier
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10.1186/s13027-020-0276-z
Identifier
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https://repositorio.uchile.cl/handle/2250/174734
Abstract
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Background The role of human polyomaviruses (HPyVs) in epithelial tumors such as head and neck carcinomas (HNSCCs) including oral and oropharyngeal carcinomas has not been established. In this study, we evaluated for the first time the presence of Merkel cell polyomavirus (MCPyV), BK human polyomavirus (BKPyV), and JC human polyomavirus (JCPyV) in HNSCCs from Chilean subjects. Methods One hundred and twenty HNSCCs were analyzed for the presence of MCPyV, BKPyV and JCPyV using real-time polymerase chain reaction procedures. In addition, 54 oral brushes from age- and sex-paired subjects were analyzed. Results Of the total of 120 HNSCCs, 15 were positive for MCPyV (12.5%). Only one case was positive for BKPyV (0.8%) and none for JCPyV (0%). In subjects without cancer, only one case (1.8%) resulted positive for MCPyV and none for JCPyV and BKPyV. MCPyV was associated with HNSCCs (p = 0.0239; OR = 7.571; 95% CI: 1.192-81.46). No association was found between age (p = 0.1996), gender (p = 0.7111) or differentiation status (p > 0.9999) and MCPyV presence in HNSCCs. Conclusions MCPyVs were detected in HNSCCs from Chilean patients and were not detected in oral brushes from patients without cancer. More studies are warranted for defining an etiological role and clinical/molecular consequences of these viruses in HNSCCs.
es_ES
Patrocinador
dc.description.sponsorship
Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) CONICYT FONDECYT 1120248/1161219 3190723
3190744
Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) 21180901 21181116
Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) CONICYT FONDAP 15130011