Psoriasis and mental health workshop report: exploring the links between psychosocial factors, psoriasis, neuroinflammation and cardiovascular disease risk
Author
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Kleyn, C. Elise
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Talbot, Peter S.
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Mehta, Nehal N.
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Sampogna, Francesca
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Bundy, Chris
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Ashcroft, Darren M.
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Kimball, Alexa B.
Author
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Van De Kerkhof, Peter
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Griffiths, Christopher E. M.
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Valenzuela Ahumada, Fernando
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Van Der Walt, Joelle M.
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Aberra, Tsion
Author
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Puig, Lluís
Admission date
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2020-06-10T19:19:06Z
Available date
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2020-06-10T19:19:06Z
Publication date
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2020
Cita de ítem
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Acta Derm Venereol 2020; 100: adv00020
es_ES
Identifier
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10.2340/00015555-3375
Identifier
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https://repositorio.uchile.cl/handle/2250/175378
Abstract
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Psoriasis is a systemic, relapsing, inflammatory disease associated with serious comorbidities including mood problems and/or unhealthy lifestyle behaviours. Cutaneous and systemic abnormalities in innate and acquired immunity play a role in its pathogenesis. The exact pathogenetic mechanism remains elusive. Evidence is accumulating that TNF-alpha, IL-17 and IL23 signalling are highly relevant as targeting these pathways reduces disease activity. Evidence suggests a strong link between psoriasis and depression in adults. The International Psoriasis Council (IPC) held a roundtable event, "Psoriasis and Mental Health", in Barcelona, Spain which focused on the presence of depression and suicidality, plus the role of neuroinflammation in psoriasis, sleep disruption and the impact of depression on cardiovascular disease outcomes. We summarize here the expert presentations to provide additional insight into the understanding of psychiatric comorbidities of psoriasis and of the impact of chronic, systemic inflammation on neuro- and cardiovascular outcomes. the associations between psoriasis and other psychiatric comorbidities are still controversial and warrant further attention.
Psoriasis and mental health workshop report: exploring the links between psychosocial factors, psoriasis, neuroinflammation and cardiovascular disease risk