The Flavonoid Agathisflavone from Poincianella pyramidalis Prevents Aminochrome Neurotoxicity
Author
dc.contributor.author
Creusa Santos, Cleonice
Author
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Muñoz Casas del Valle, Patricia
Author
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Almeida, Áurea María A. N.
Author
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Pereira de Lima David, Juceni
Author
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Jorge Mauricio, David
Author
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Costa, Silvia Lima
Author
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Segura Aguilar, Juan
Author
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Amaral Silva, Víctor Diogenes
Admission date
dc.date.accessioned
2020-08-22T21:48:18Z
Available date
dc.date.available
2020-08-22T21:48:18Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Neurotoxicity Research (2020)
es_ES
Identifier
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10.1007/s12640-020-00237-6
Identifier
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https://repositorio.uchile.cl/handle/2250/176523
Abstract
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Flavonoids have been suggested to protect dopaminergic neurons in Parkinson’s disease based on studies that used exogenous
neurotoxins. In this study, we tested the protective ability of agathisflavone in SH-SY5Y cells exposed to the endogenous
neurotoxin aminochrome. The ability of aminochrome to induce loss of lysosome acidity is an important mechanism of its
neurotoxicity. We demonstrated that the flavonoid inhibited cellular death and lysosomal dysfunction induced by aminochrome.
In addition, we demonstrated that the protective effect of agathisflavone was suppressed by antagonists of estrogen receptors
(ERα and ERβ). These results suggest lysosomal protection and estrogen signaling as mechanisms involved in agathisflavone
neuroprotection in a Parkinson’s disease study model.
es_ES
Patrocinador
dc.description.sponsorship
Coordenacao de Apoio de Pessoal de Nivel Superior
CAPES/PVE-189576/09-2014
Fundacao de Apoio a Pesquisa do Estado da Bahia (FAPESB)
JCB0057/2016
National Council for Scientific and Technological Development (CNPq)
Edital Universal/2018-429127/2018-9