Cochlear synaptopathy: new findings in animal and human research
Author
dc.contributor.author
Aedo Sánchez, Cristian
Author
dc.contributor.author
Aguilar Vidal, Enzo
Admission date
dc.date.accessioned
2020-11-06T15:19:00Z
Available date
dc.date.available
2020-11-06T15:19:00Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Reviews in the Neurosciences Aug 2020
es_ES
Identifier
dc.identifier.other
10.1515/revneuro-2020-0002
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/177594
Abstract
dc.description.abstract
In animal models, prolonged exposure (2 h) to high-level noise causes an irreparable damage to the synapses between the inner hair cells and auditory nerve fibers within the cochlea. Nevertheless, this injury does not necessarily alter the hearing threshold. Similar findings have been observed as part of typical aging in animals. This type of cochlear synaptopathy, popularly called "hidden hearing loss," has been a significant issue in neuroscience research and clinical audiology scientists. The results obtained in different investigations are inconclusive in their diagnosis and suggest new strategies for both prognosis and treatment of cochlear synaptopathy. Here we review the major physiological findings regarding cochlear synaptopathy in animals and humans and discuss mathematical models. We also analyze the potential impact of these results on clinical practice and therapeutic options.