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Authordc.contributor.authorMagrin, Gabriel Leonardo 
Authordc.contributor.authorStrauss Avendaño, Franz 
Authordc.contributor.authorMagalhães Benfatti, César Augusto 
Authordc.contributor.authorCople Maia, Lucianne 
Authordc.contributor.authorGruber, Reinhard 
Cita de ítemdc.identifier.citationInt. J. Mol. Sci. 21 (2): 4895es_ES
Abstractdc.description.abstractShort-chain fatty acids (SCFA), bacterial metabolites released from dental biofilm, are supposed to target the oral epithelium. There is, however, no consensus on how SCFA affect the oral epithelial cells. The objective of the present study was to systematically review the available in vitro evidence of the impact of SCFA on human oral epithelial cells in the context of periodontal disease. A comprehensive electronic search using five databases along with a grey literature search was performed. In vitro studies that evaluated the effects of SCFA on human oral epithelial cells were eligible for inclusion. Risk of bias was assessed by the University of Bristol's tool for assessing risk of bias in cell culture studies. Certainty in cumulative evidence was evaluated using GRADE criteria (grading of recommendations assessment, development, and evaluation). Of 3591 records identified, 10 were eligible for inclusion. A meta-analysis was not possible due to the heterogeneity between the studies. The risk of bias across the studies was considered "serious" due to the presence of methodological biases. Despite these limitations, this review showed that SCFA negatively affect the viability of oral epithelial cells by activating a series of cellular events that includes apoptosis, autophagy, and pyroptosis. SCFA impair the integrity and presumably the transmigration of leucocytes through the epithelial layer by changing junctional and adhesion protein expression, respectively. SCFA also affect the expression of chemokines and cytokines in oral epithelial cells. Future research needs to identify the underlying signaling cascades and to translate the in vitro findings into preclinical models.es_ES
Patrocinadordc.description.sponsorshipCAPES Austrian Science Fund (FWF) 4072-B28es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceInternational Journal of Molecular Scienceses_ES
Keywordsdc.subjectShort-chain fatty acidses_ES
Keywordsdc.subjectEpithelial cellses_ES
Keywordsdc.subjectPeriodontal diseasees_ES
Keywordsdc.subjectIn vitroes_ES
Keywordsdc.subjectSystematic reviewes_ES
Títulodc.titleEffects of short-chain fatty acids on human oral epithelial cells and the potential impact on periodontal disease: a systematic review of In vitro studieses_ES
Document typedc.typeArtículo de revistaes_ES
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile