New Copper(I) complex with a coumarin as ligand with antibacterial activity againstFlavobacterium psychrophilum

Abstract

A new copper (I) complex, [Cu(NN1)(2)](ClO4)(,)was synthesized, where NN(1)was a imine ligand 6-((quinolin-2-ylmethylene)amino)-2H-chromen-2-one obtained by a derivatization of natural compound coumarin. The structural characterization in solution was done by NMR techniques, UV-Vis and cyclic voltammetry. The potential antibacterial effect of [Cu(NN1)(2)](ClO4)(,)was assessed forF. psychrophilumisolated 10094.F. psychrophilumis a Gram-negative bacterium which causes diseases such as bacterial cold-water disease and rainbow trout fry syndrome, causing large economic losses in the freshwater salmonid aquaculture industry. This complex show to have antibacterial activity againstF. psychrophilum10094 at non-cytotoxic concentration in cell line derived from trout (F. psychrophilum10094 IC(50)16.0 +/- 0.9; RT-GUT IC(50)53.0 +/- 3.1 mu g/mL).