Author | dc.contributor.author | Cafferata Chea, Emilio | |
Author | dc.contributor.author | Monasterio Ocares, Gustavo | |
Author | dc.contributor.author | Castillo Franzoy, Francisca | |
Author | dc.contributor.author | Carvajal Pavez, Paola | |
Author | dc.contributor.author | Flores Sepúlveda, Guillermo | |
Author | dc.contributor.author | Díaz Guzmán, Walter | |
Author | dc.contributor.author | Fuentes del Campo, Aler | |
Author | dc.contributor.author | Vernal Astudillo, Rolando | |
Admission date | dc.date.accessioned | 2021-01-13T22:27:06Z | |
Available date | dc.date.available | 2021-01-13T22:27:06Z | |
Publication date | dc.date.issued | 2020 | |
Cita de ítem | dc.identifier.citation | Oral Diseases Sep 2020 | es_ES |
Identifier | dc.identifier.other | 10.1111/odi.13623 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/178253 | |
Abstract | dc.description.abstract | Objective This study aimed to determine the expression of distinct matrix metalloproteinases, cytokines, and bone resorptive factors in temporomandibular joint osteoarthritis (TMJ-OA) patients and their association with joint pain, mouth opening, and subchondral bone degeneration. Materials and methods Twelve patients affected with TMJ-OA (n = 5), disk displacement without reduction (DDWoR) (n = 3), or disk displacement with reduction (DDWR) (n = 4) were selected. Joint pain was quantified by using visual analog scale, mouth opening was quantified at the maximum pain-free aperture, and bone degeneration was quantified using joint imaging. Synovial fluid samples were collected and immediately processed for cell and synovial fluid recovering. From cells, the MMP-1, MMP-2, MMP-8, MMP-13, IL-6, IL-23, and TNF-alpha expression was quantified by qPCR. From synovial fluid, the RANKL and OPG levels were quantified by ELISA. Results Higher levels of MMP-1, MMP-8, MMP-13, IL-6, IL-23, TNF-alpha, and RANKL/OPG ratio were detected in TMJ-OA compared with DDWoR and DDWR patients (p < .05). Joint pain significantly correlated with TNF-alpha levels (r = .975,p = .029). Besides, imaging signs of bone degeneration significantly correlated with RANKL/OPG ratio (r = .949,p = .042). Conversely, mouth opening did not correlate with any of the analyzed mediators. Conclusion During TMJ-OA, a pathological response characterized by the overexpression of TNF-alpha and RANKL/OPG could be involved in joint pain and subchondral bone degeneration. | es_ES |
Patrocinador | dc.description.sponsorship | FONDECYT grant from the Chilean Governmental Agencia Nacional de Investigación y Desarrollo (ANID)
1181780
Graduate School of the Faculty of Dentistry, Universidad de Chile
ANID
21170297 | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | Wiley | es_ES |
Source | dc.source | Oral Diseases | es_ES |
Keywords | dc.subject | Cytokines | es_ES |
Keywords | dc.subject | MMPs | es_ES |
Keywords | dc.subject | OPG | es_ES |
Keywords | dc.subject | RANKL | es_ES |
Keywords | dc.subject | Temporomandibular osteoarthritis | es_ES |
Título | dc.title | Overexpression of MMPs, cytokines, and RANKL/OPG in temporomandibular joint osteoarthritis and their association with joint pain, mouth opening, and bone degeneration: A preliminary report | es_ES |
Document type | dc.type | Artículo de revista | |
dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | es_ES |
Cataloguer | uchile.catalogador | ctc | es_ES |
Indexation | uchile.index | Artículo de publicación ISI | es_ES |