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Authordc.contributor.authorCafferata Chea, Emilio 
Authordc.contributor.authorMonasterio Ocares, Gustavo 
Authordc.contributor.authorCastillo Franzoy, Francisca 
Authordc.contributor.authorCarvajal Pavez, Paola 
Authordc.contributor.authorFlores Sepúlveda, Guillermo 
Authordc.contributor.authorDíaz Guzmán, Walter 
Authordc.contributor.authorFuentes del Campo, Aler 
Authordc.contributor.authorVernal Astudillo, Rolando 
Admission datedc.date.accessioned2021-01-13T22:27:06Z
Available datedc.date.available2021-01-13T22:27:06Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationOral Diseases Sep 2020es_ES
Identifierdc.identifier.other10.1111/odi.13623
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/178253
Abstractdc.description.abstractObjective This study aimed to determine the expression of distinct matrix metalloproteinases, cytokines, and bone resorptive factors in temporomandibular joint osteoarthritis (TMJ-OA) patients and their association with joint pain, mouth opening, and subchondral bone degeneration. Materials and methods Twelve patients affected with TMJ-OA (n = 5), disk displacement without reduction (DDWoR) (n = 3), or disk displacement with reduction (DDWR) (n = 4) were selected. Joint pain was quantified by using visual analog scale, mouth opening was quantified at the maximum pain-free aperture, and bone degeneration was quantified using joint imaging. Synovial fluid samples were collected and immediately processed for cell and synovial fluid recovering. From cells, the MMP-1, MMP-2, MMP-8, MMP-13, IL-6, IL-23, and TNF-alpha expression was quantified by qPCR. From synovial fluid, the RANKL and OPG levels were quantified by ELISA. Results Higher levels of MMP-1, MMP-8, MMP-13, IL-6, IL-23, TNF-alpha, and RANKL/OPG ratio were detected in TMJ-OA compared with DDWoR and DDWR patients (p < .05). Joint pain significantly correlated with TNF-alpha levels (r = .975,p = .029). Besides, imaging signs of bone degeneration significantly correlated with RANKL/OPG ratio (r = .949,p = .042). Conversely, mouth opening did not correlate with any of the analyzed mediators. Conclusion During TMJ-OA, a pathological response characterized by the overexpression of TNF-alpha and RANKL/OPG could be involved in joint pain and subchondral bone degeneration.es_ES
Patrocinadordc.description.sponsorshipFONDECYT grant from the Chilean Governmental Agencia Nacional de Investigación y Desarrollo (ANID) 1181780 Graduate School of the Faculty of Dentistry, Universidad de Chile ANID 21170297es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherWileyes_ES
Sourcedc.sourceOral Diseaseses_ES
Keywordsdc.subjectCytokineses_ES
Keywordsdc.subjectMMPses_ES
Keywordsdc.subjectOPGes_ES
Keywordsdc.subjectRANKLes_ES
Keywordsdc.subjectTemporomandibular osteoarthritises_ES
Títulodc.titleOverexpression of MMPs, cytokines, and RANKL/OPG in temporomandibular joint osteoarthritis and their association with joint pain, mouth opening, and bone degeneration: A preliminary reportes_ES
Document typedc.typeArtículo de revista
dcterms.accessRightsdcterms.accessRightsAcceso a solo metadatoses_ES
Catalogueruchile.catalogadorctces_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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