When Endoplasmic Reticulum Proteostasis Meets the DNA Damage Response
Author
dc.contributor.author
González Quiroz, Matías
Author
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Blondel, Alice
Author
dc.contributor.author
Sagredo, Alfredo
Author
dc.contributor.author
Hetz Flores, Claudio
Author
dc.contributor.author
Chevet, Eric
Author
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Pedeux, Remy
Admission date
dc.date.accessioned
2021-03-22T20:08:14Z
Available date
dc.date.available
2021-03-22T20:08:14Z
Publication date
dc.date.issued
2020
Cita de ítem
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Trends in Cell Biology, November 2020, Vol. 30, No. 11
es_ES
Identifier
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10.1016/j.tcb.2020.09.002
Identifier
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https://repositorio.uchile.cl/handle/2250/178737
Abstract
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Sustaining both proteome and genome integrity (GI) requires the integration of a wide range of mechanisms and signaling pathways. These comprise, in particular, the unfolded protein response (UPR) and the DNA damage response (DDR). These adaptive mechanisms take place respectively in the endoplasmic reticulum (ER) and in the nucleus. UPR and DDR alterations are associated with aging and with pathologies such as degenerative diseases, metabolic and inflammatory disorders, and cancer. We discuss the emerging signaling crosstalk between UPR stress sensors and the DDR, as well as their involvement in cancer biology.
es_ES
Patrocinador
dc.description.sponsorship
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
PCHA/Doctorado Nacional/2016-21160232
Association pour les Recommendations en Dermatologie (ARED)/INSERM Region Bretagne, France
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT
3190738
Fondo de Financiamiento de Centros de Investigacion en Areas Prioritarias (FONDAP), Chile
GERO15150012
FONDAP program, Chile
15150012
Millennium Institute, Chile
P09-015-F
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDEF
ID16I10223
D11E1007
Ecos-CONICYT, Chile
C17S02
Institut National du Cancer (INCA) France
French National Research Agency (ANR)
EU Horizon 2020 Marie Sklodowska-Curie Action (MSCA), France
ITN-675448
MSCA RISE-734749
Fondation pour la Recherche Medicale
DEQ20180339169
Ligue Contre le Cancer Grand Ouest, France
Institut National de la Sante et de la Recherche Medicale (Inserm)
FONDECYT-T1180186