Mastering organismal aging through the endoplasmic reticulum proteostasis network
Author
dc.contributor.author
Taylor, Rebecca C.
Author
dc.contributor.author
Hetz Flores, Claudio
Admission date
dc.date.accessioned
2021-03-30T18:55:25Z
Available date
dc.date.available
2021-03-30T18:55:25Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Aging Cell. 2020;19:e13265.
es_ES
Identifier
dc.identifier.other
10.1111/acel.13265
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/178868
Abstract
dc.description.abstract
The aging process is characterized by a progressive decline in the function of most tissues, representing the main risk factor in the development of a variety of human diseases. Studies in multiple animal models have demonstrated that interventions that improve the capacity to maintain endoplasmic reticulum (ER) proteostasis prolong life and healthspan. ER stress is monitored by the unfolded protein response (UPR), a signaling pathway that mediates adaptive processes to restore proteostasis or the elimination of damaged cells by apoptosis. Here, we discuss recent advances in understanding the significance of the UPR to aging and its implications for the maintenance of cell physiology of various cell types and organs. The possible benefits of targeting the UPR to extend healthspan and reduce the risk of developing age-related diseases are also discussed.
es_ES
Patrocinador
dc.description.sponsorship
ANID/FONDAP program
15150012
Takeda Pharmaceutical Company Ltd
P09015-F
FONDEF
ID16I10223
D11E1007
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT
1180186
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
C17S02
Michael J Fox For Parkinson's research target validation
12473.01
Office of Naval Research
20RT0419
UK Research & Innovation (UKRI)
Medical Research Council UK (MRC)
European Commission