Demographic history and selection at HLA loci in Native Americans
Author
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Single, Richard M.
Author
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Meyer, Diogo
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Nunes, Kelly
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Santos, Rodrigo
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Hunemeier, Tábita
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Maiers, Martin
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Hurley, Carolyn K
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Bedoya, Gabriel
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Gallo, Carla
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Hurtado, Ana Magdalena
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Llop Romero, Elena
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Petzl-Erler, Maria L.
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Poletti, Giovanni
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Rothhammer, Francisco
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Tsuneto, Luiza
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Klitz, William
Author
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Ruiz Linares, Andrés
Admission date
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2021-04-23T22:13:44Z
Available date
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2021-04-23T22:13:44Z
Publication date
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2020
Cita de ítem
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PLoS ONE 15(11): e0241282 (2020)
es_ES
Identifier
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10.1371/journal.pone.0241282
Identifier
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https://repositorio.uchile.cl/handle/2250/179272
Abstract
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The American continent was the last to be occupied by modern humans, and native populations bear the marks of recent expansions, bottlenecks, natural selection, and population substructure. Here we investigate how this demographic history has shaped genetic variation at the strongly selected HLA loci. In order to disentangle the relative contributions of selection and demography process, we assembled a dataset with genome-wide microsatellites and HLA-A, -B, -C, and -DRB1 typing data for a set of 424 Native American individuals. We find that demographic history explains a sizeable fraction of HLA variation, both within and among populations. A striking feature of HLA variation in the Americas is the existence of alleles which are present in the continent but either absent or very rare elsewhere in the world. We show that this feature is consistent with demographic history (i.e., the combination of changes in population size associated with bottlenecks and subsequent population expansions). However, signatures of selection at HLA loci are still visible, with significant evidence selection at deeper timescales for most loci and populations, as well as population differentiation at HLA loci exceeding that seen at neutral markers.
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Patrocinador
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Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP)
12/18010-0