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Authordc.contributor.authorContreras, G. 
Authordc.contributor.authorBarrientos, C 
Authordc.contributor.authorMoscoso, R. 
Authordc.contributor.authorÁlvarez Lueje, Alejandro 
Authordc.contributor.authorSquella Serrano, Juan
Admission datedc.date.accessioned2021-06-09T21:51:13Z
Available datedc.date.available2021-06-09T21:51:13Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationMicrochemical Journal 159 (2020) 105422es_ES
Identifierdc.identifier.other10.1016/j.microc.2020.105422
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/180082
Abstractdc.description.abstractIn this work, we have both synthesized and studied 4-phenylbutyl-3,5-dinitrobenzoate (3,5-DNBPh) as a potential precursor of an electrocatalytic mediator for the oxidation of NADH, with the di-nitro compound immobilized in a three-dimensional network of glassy carbon electrodes modified with MWCNTs. This di-nitro compound is activated electrochemically to selectively generate one nitroso-hydroxylamine redox pair, which ultimately acts as a redox mediator of NADH oxidation. Thus, NADH electrocatalysis displaces the oxidation potential of NADH with the formation of a single voltammetric peak, the displacement occurs from Ep = +0.374 V in GCE/MWCNT to +0.001 V in GCE/MWCNT/3,5-DNBPh (very close to 0 V, Delta Ep = 0.373 V). The 4-phenylbutyl-3,5-dinitrobenzoate mediator is sensitive to NADH concentration, and a linear regression between 0.1 and 0.6 mM NADH (r(2) = 0.99) was obtained, with a detection limit of 22.3 mu M (S/N = 3) and a quantification limit of 74.2 mu M (S/N = 10). The developed modified electrode presents low NADH electrocatalytic oxidation potentials, and an interesting and novel advantage is that the preparation of the electrodes is fast, clean and effective, allowing biosensors to be obtained in a few steps.es_ES
Patrocinadordc.description.sponsorshipComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1170054 1210899
Lenguagedc.language.isoenes_ES
Publisherdc.publisherElsevieres_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceMicrochemical Journales_ES
Keywordsdc.subjectElectrocatalysises_ES
Keywordsdc.subjectMWCNTes_ES
Keywordsdc.subjectNADHes_ES
Keywordsdc.subjectNitro compoundes_ES
Keywordsdc.subjectModified electrodeses_ES
Títulodc.titleElectrocatalytic determination of NADH by means of electrodes modified with MWCNTs and nitroaromatic compoundses_ES
Document typedc.typeArtículo de revistaes_ES
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorcrbes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile