Safety and effectiveness of progressive moderate-to-vigorous intensity elastic resistance training on physical function and pain in people with hemophilia
Author
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Calatayud, Joaquín
Author
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Pérez Alenda, Sofía
Author
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Carrasco, Juan J.
Author
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Cruz Montecinos, Carlos
Author
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Andersen, Lars L.
Author
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Bonanad, Santiago
Author
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Querol, Felipe
Author
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Megías Vericat, Juan E.
Author
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Casaña, José
Admission date
dc.date.accessioned
2021-06-15T21:48:24Z
Available date
dc.date.available
2021-06-15T21:48:24Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Physical Therapy Volume 100 Number 9 (2020)
es_ES
Identifier
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10.1093/ptj/pzaa106
Identifier
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https://repositorio.uchile.cl/handle/2250/180134
Abstract
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Objective. Strength training is recommended for people with hemophilia; however,
published data are anecdotal and have methodological limitations. The purpose of this
study was to evaluate the safety and effectiveness of progressive moderate-to-vigorous
intensity elastic resistance training on physical function and pain in this patient population.
Methods. A randomized controlled trial was conducted in a university laboratory setting
where 20 patients (17 with severe, 1 with moderate, and 2 with mild hemophilia) aged 21 to
53 years received evaluations at baseline and 8-week follow-up. Participants were allocated
to intervention (progressive strength training) or control (usual daily activities) groups. The
intervention group trained 2 days per week during 8 weeks with elastic resistance. Intensity
during the first 2 weeks was a 20-repetition maximum and increased progressively toward
15, 12, and finally 10 repetition maximum. The primary outcome was muscle strength.
Secondary outcomes were the Timed “Up and Go” Test score, sit-to-stand, range of motion,
Haemophilia Joint Health Score, kinesiophobia score, global impression of pain change,
general self-rated health status, and desire to exercise.
Results. The intervention group showed greater strength improvements than the control
group in almost all of the joints, with moderate to high effect sizes. The intervention
group also showed better Timed “Up and Go” and sit-to-stand scores than the control
group (moderate effect size), greater range of motion at the knee flexion with the right leg
(trivial effect size), and better Haemophilia Joint Health Score at the left knee (small effect
size). The intervention group showed greater overall pain reduction, self-rated overall
status, and desire to exercise than the control group.
Conclusions. Progressive strength training with elastic resistance performed twice a
week during 8 weeks is safe and effective in people with hemophilia to improve muscle
strength and functional capacity, reduce general pain, and improve self-rated health status
and desire to exercise.
Impact. This study provides evidence for the use of a specific strength training regimen
for people with hemophilia.
Lay Summary. People with hemophilia of differing levels of severity, with adequate
coverage with clotting factor, can safely engage in progressive strength training and can
improve their functioning.
es_ES
Patrocinador
dc.description.sponsorship
Baxalta US Inc, Banockburn, Illinois, (USA), Takeda group of companies
H15-29504
Safety and effectiveness of progressive moderate-to-vigorous intensity elastic resistance training on physical function and pain in people with hemophilia