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Authordc.contributor.authorBejarano, Julián 
Authordc.contributor.authorRojas, Aldo 
Authordc.contributor.authorRamírez Sagredo, Andrea 
Authordc.contributor.authorRiveros Salvatierra, Ana 
Authordc.contributor.authorMorales Zavala, Francisco 
Authordc.contributor.authorFlores, Yvo 
Authordc.contributor.authorRiquelme Meléndez, Jaime 
Authordc.contributor.authorGuzmán, Fanny 
Authordc.contributor.authorAraya, Eyleen 
Authordc.contributor.authorChiong Lay, Mario 
Authordc.contributor.authorOcaranza, María Paz 
Authordc.contributor.authorMorales Montecinos, Javier 
Authordc.contributor.authorVillamizar Sarmiento, María Gabriela 
Authordc.contributor.authorSánchez Vergara, Gina 
Authordc.contributor.authorLavandero González, Sergio
Authordc.contributor.authorKogan, Marcelo J. 
Cita de ítemdc.identifier.citationJournal of Controlled Release 328 (2020) 859–872es_ES
Abstractdc.description.abstractAngiotensin-(1-9), a component of the non-canonical renin-angiotensin system, has a short half-life in blood. This peptide has shown to prevent and/or attenuate hypertension and cardiovascular remodeling. A controlled release of angiotensin-(1-9) is needed for its delivery to the heart. Our aim was to develop a drug delivery system for angiotensin-(1-9). Thermosensitive liposomes (LipoTherm) were prepared with gold nanoclusters (LipoThermAuNC) to increase the stability and reach a temporal and spatial control of angiotensin-(1-9) release. Encapsulation efficiencies of nearly 50% were achieved in LipoTherm, reaching a total angiotensin-(1-9) loading of around 180 mu M. This angiotensin-(1-9)-loaded LipoTherm sized around 100 nm and exhibited a phase transition temperature of 43.C. AuNC were grown on LipoTherm and the new hybrid nanosystem showed energy absorption in the near-infrared (NIR) wavelength range. By NIR laser irradiation, a controlled release of angiotensin-(1-9) was achieved from the LipoTherm-AuNC nanosystem. These nanosystems did not show any cytotoxic effect on cultured cardiomyocytes. Biological activity of angiotensin-(1-9) released from the LipoTherm-AuNCbased nanosystem was confirmed using an ex vivo Langendorff heart model.es_ES
Patrocinadordc.description.sponsorshipAgencia Nacional de Investigacion y Desarrollo (ANID), Chile FONDAP 15130011 Puente Pontificia Universidad Catolica de Chile 033/2020 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1190623 1200490 Bayer AG 2017-08-2260 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT PIA/ANILLOS ACT192144 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 3160323 FONDEQUIP EQM160157 EQM170111es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceJournal of Controlled Releasees_ES
Keywordsdc.subjectCardiovascular diseaseses_ES
Keywordsdc.subjectThermosensitive liposomeses_ES
Títulodc.titleLight-induced release of the cardioprotective peptide angiotensin-(1-9) from thermosensitive liposomes with gold nanoclusterses_ES
Document typedc.typeArtículo de revistaes_ES
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Indexationuchile.indexArtículo de publicación ISI
Indexationuchile.indexArtículo de publicación SCOPUS

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile