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Authordc.contributor.authorHoare, Anilei 
Authordc.contributor.authorWang, Hui 
Authordc.contributor.authorMeethil, Archana 
Authordc.contributor.authorAbusleme Ramos, Loreto 
Authordc.contributor.authorHong, Bo-Young 
Authordc.contributor.authorMoutsopoulos, Niki M. 
Authordc.contributor.authorMarsh, Philip D. 
Authordc.contributor.authorHajishengallis, George 
Authordc.contributor.authorDíaz, Patricia I. 
Admission datedc.date.accessioned2021-07-05T22:30:36Z
Available datedc.date.available2021-07-05T22:30:36Z
Publication datedc.date.issued2020
Cita de ítemdc.identifier.citationIsme Journal Volumen: 15 Número: 5 Páginas: 1490-1504 Dec 2020 (Early Access)es_ES
Identifierdc.identifier.other10.1038/s41396-020-00865-y
Identifierdc.identifier.urihttp://repositorio.uchile.cl/handle/2250/180437
Abstractdc.description.abstractRecent studies describe in detail the shifts in composition of human-associated polymicrobial communities from health to disease. However, the specific processes that drive the colonization and overgrowth of pathogens within these communities remain incompletely understood. We used in vitro culture systems and a disease-relevant mouse model to show that population size, which determines the availability of an endogenous diffusible small molecule, limits the growth, colonization, and in vivo virulence of the human oral pathogen Porphyromonas gingivalis. This bacterial pathogen overcomes the requirement for an endogenous cue by utilizing a cell-density dependent, growth-promoting, soluble molecule provided by the symbiotic early colonizer Veillonella parvula, but not produced by other commensals tested. Our work shows that exchange of cell-density-dependent diffusible cues between specific early and late colonizing species in a polymicrobial community drives microbial successions, pathogen colonization and disease development, representing a target process for manipulation of the microbiome towards the healthy state.es_ES
Patrocinadordc.description.sponsorshipIntramural Program (NMM) of The National Institute of Dental and Craniofacial Research, National Institutes of Health Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 11180505 R21DE023967 R01DE015254es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherSpringernaturees_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/cl/*
Sourcedc.sourceIsme Journales_ES
Keywordsdc.subjectPorphyromonas-gingivalises_ES
Keywordsdc.subjectSubgingival microbiomees_ES
Keywordsdc.subjectChronic periodontitises_ES
Keywordsdc.subjectSusceptibilityes_ES
Keywordsdc.subjectColonizationes_ES
Keywordsdc.subjectInflammationes_ES
Keywordsdc.subjectAcquisitiones_ES
Keywordsdc.subjectGingivitises_ES
Keywordsdc.subjectBiofilmses_ES
Títulodc.titleA cross-species interaction with a symbiotic commensal enables cell-density-dependent growth and in vivo virulence of an oral pathogenes_ES
Document typedc.typeArtículo de revistaes_ES
dcterms.accessRightsdcterms.accessRightsAcceso Abierto
Catalogueruchile.catalogadorcrbes_ES
Indexationuchile.indexArtículo de publicación ISIes_ES


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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile