Riesgo de infección en pacientes
con enfermedades inmunológicas y
oncológicas tratados con biológicos:
revisión panorámica
Author
dc.contributor.author
Gambra, María Pilar
Author
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Montesinos, Juan José
Author
dc.contributor.author
Valenzuela, María Teresa
Author
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Cárcamo, Marcela Eliana
Author
dc.contributor.author
Cavada Chacón, Gabriel
Admission date
dc.date.accessioned
2021-07-06T22:10:25Z
Available date
dc.date.available
2021-07-06T22:10:25Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Rev. Med Chile 2020; 148: 1155-1170
es_ES
Identifier
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0034-9887
Identifier
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0717-6163
Identifier
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https://repositorio.uchile.cl/handle/2250/180465
Abstract
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Biological medications are effective for the treatment of cancer and inflammatory diseases. The aim of this review is to summarize the available evidence in systematic reviews or meta-analyses about the risk of infection in patients with cancer, arthritis, psoriasis and inflammatory bowel disease who use biological medications. We included systematic reviews or meta-analyses of controlled clinical trials and case/control studies that analyze infections during and after treatment with FDA-approved biological medications for the treatment of cancer, arthritis, inflammatory bowel disease and psoriasis, both in adults and children. The following databases were consulted: PubMed, Epistemonikos, Crochrane reviews, JIB, and Prospero. A quality guideline (AMSTAR) was applied to the selected studies. We included 26 studies. The risk of infections in patients with solid organ cancer is consistent in the literature. In psoriasis there is a risk of non-serious infections. In arthritis and other inflammatory diseases there is a risk of serious infections. In inflammatory bowel disease there is a risk for opportunistic infections. In conclusion, in patients with cancer and inflammatory diseases use biological medications entails a risk of infection. The evidence is different depending on the underlying disease of each patient.