Author | dc.contributor.author | Petersson, Per | |
Author | dc.contributor.author | Kuehn, Andrea A. | |
Author | dc.contributor.author | Neumann, Wolf-Julián | |
Author | dc.contributor.author | Fuentes, Rómulo | |
Admission date | dc.date.accessioned | 2021-07-30T19:51:12Z | |
Available date | dc.date.available | 2021-07-30T19:51:12Z | |
Publication date | dc.date.issued | 2020 | |
Cita de ítem | dc.identifier.citation | Recent Advances in Parkinson's Disease (2020) 252 Págs. 525-557 | es_ES |
Identifier | dc.identifier.other | 10.1016/bs.pbr.2020.02.002 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/180791 | |
Abstract | dc.description.abstract | Oscillations are a naturally occurring phenomenon in highly interconnected dynamical systems.
However, it is thought that excessive synchronized oscillations in brain circuits can be detrimental for
many brain functions by disrupting neuronal information processing. Because synchronized basal
ganglia oscillations are a hallmark of Parkinson's disease (PD), it has been suggested that aberrant
rhythmic activity associated with symptoms of the disease could be used as a physiological biomarker to
guide pharmacological and electrical neuromodulatory interventions. We here briefly review the various
manifestations of basal ganglia oscillations observed in human subjects and in animal models of PD. In
this context, we also review the evidence supporting a pathophysiological role of different oscillations
for the suppression of voluntary movements as well as for the induction of excessive motor activity. In
light of these findings, it is discussed how oscillations could be used to guide a more precise targeting of
dysfunctional circuits to obtain improved symptomatic treatment of PD. | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | Academic Press - Elsevier Science | es_ES |
Source | dc.source | Recent Advances in Parkinson's Disease | es_ES |
Keywords | dc.subject | Hypokinesia | es_ES |
Keywords | dc.subject | Hyperkinesia | es_ES |
Keywords | dc.subject | Levodopa | es_ES |
Keywords | dc.subject | Non-motor symptoms | es_ES |
Keywords | dc.subject | LFP | es_ES |
Keywords | dc.subject | Neuronal circuits | es_ES |
Keywords | dc.subject | Neurophysiology | es_ES |
Título | dc.title | Basal ganglia oscillations as biomarkers for targeting circuit dysfunction in Parkinson's disease | es_ES |
Document type | dc.type | Artículo de revista | es_ES |
dcterms.accessRights | dcterms.accessRights | Acceso a solo metadatos | es_ES |
Cataloguer | uchile.catalogador | cfr | es_ES |
Indexation | uchile.index | Artículo de publicación ISI | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |