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Authordc.contributor.authorVillar Fincheira, Paulina 
Authordc.contributor.authorSanhueza Olivares, Fernanda 
Authordc.contributor.authorNorambuena Soto, Ignacio 
Authordc.contributor.authorCancino Arenas, Nicole 
Authordc.contributor.authorHernández Vargas, Felipe 
Authordc.contributor.authorTroncoso Cotal, Rodrigo 
Authordc.contributor.authorGabrielli, Luigi 
Authordc.contributor.authorChiong Lay, Mario 
Cita de ítemdc.identifier.citationFrontiers in Molecular Biosciences March 2021 Volume 8 Article 641734es_ES
Abstractdc.description.abstractIL-6 is usually described as a pleiotropic cytokine produced in response to tissue injury or infection. As a pro-inflammatory cytokine, IL-6 activates innate and adaptative immune responses. IL-6 is released in the innate immune response by leukocytes as well as stromal cells upon pattern recognition receptor activation. IL-6 then recruits immune cells and triggers B and T cell response. Dysregulated IL-6 activity is associated with pathologies involving chronic inflammation and autoimmunity, including atherosclerosis. However, IL-6 is also produced and released under beneficial conditions, such as exercise, where IL-6 is associated with the anti-inflammatory and metabolic effects coupled with physical adaptation to intense training. Exercise-associated IL-6 acts on adipose tissue to induce lipogenesis and on arteries to induce adaptative vascular remodeling. These divergent actions could be explained by complex signaling networks. Classical IL-6 signaling involves a membrane-bound IL-6 receptor and glycoprotein 130 (gp130), while trans-signaling relies on a soluble version of IL-6R (sIL-6R) and membranebound gp130. Trans-signaling, but not the classical pathway, is regulated by soluble gp130. In this review, we discuss the similarities and differences in IL-6 cytokine and myokine signaling to explain the differential and opposite effects of this protein during inflammation and exercise, with a special focus on the vascular system.es_ES
Patrocinadordc.description.sponsorshipComision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1180157 1170963 FONDAP 15130011es_ES
Publisherdc.publisherFrontiers Mediaes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 Chile*
Link to Licensedc.rights.uri*
Sourcedc.sourceFrontiers in Molecular Bioscienceses_ES
Keywordsdc.subjectSoluble IL-6 receptores_ES
Keywordsdc.subjectVascular remodelinges_ES
Keywordsdc.subjectVascular smooth muscle cellses_ES
Títulodc.titleRole of interleukin-6 in vascular health and diseasees_ES
Document typedc.typeArtículo de revista
Indexationuchile.indexArtículo de publicación ISIes_ES

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Attribution-NonCommercial-NoDerivs 3.0 Chile
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 Chile