Vascular endothelial growth factor: A translational view in oral non-communicable diseases
Bordagaray San Martín, María José
Hernández Ríos, Emma Marcela
Cita de ítem
Biomolecules 2021, 11, 85.
Vascular endothelial growth factors (VEGFs) are vital regulators of angiogenesis that are
expressed in response to soluble mediators, such as cytokines and growth factors. Their physiologic
functions include blood vessel formation, regulation of vascular permeability, stem cell and
monocyte/macrophage recruitment and maintenance of bone homeostasis and repair. In addition,
angiogenesis plays a pivotal role in chronic pathologic conditions, such as tumorigenesis, inflammatory
immune diseases and bone loss. According to their prevalence, morbidity and mortality,
inflammatory diseases affecting periodontal tissues and oral cancer are relevant non-communicable
diseases. Whereas oral squamous cell carcinoma (OSCC) is considered one of the most common
cancers worldwide, destructive inflammatory periodontal diseases, on the other hand, are amongst
the most prevalent chronic inflammatory conditions affecting humans and also represent the main
cause of tooth loss in adults. In the recent years, while knowledge regarding the role of VEGF
signaling in common oral diseases is expanding, new potential translational applications emerge.
In the present narrative review we aim to explore the role of VEGF signaling in oral cancer and
destructive periodontal inflammatory diseases, with emphasis in its translational applications as
potential biomarkers and therapeutic targets.
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT 1200098
Type of license
Attribution-NonCommercial-NoDerivs 3.0 United States