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Authordc.contributor.authorDíaz Soler, Felipe Arturo Sebastián
Authordc.contributor.authorRodríguez Navarro, Carlos
Authordc.contributor.authorRuiz Agudo, Encarnación
Authordc.contributor.authorNeira Carrillo, Andrónico David
Cita de ítemdc.identifier.citationNanomaterials 2021, 11, 235es_ES
Abstractdc.description.abstractIn this work, calcium oxalate (CaOx) precursors were stabilized by poly(acrylic acid) (PAA) as an additive under in vitro crystallization assays involving the formation of pre-nucleation clusters of CaOx via a non-classical crystallization (NCC) pathway. The in vitro crystallization of CaOx was carried out in the presence of 10, 50 and 100 mg/L PAA by using automatic calcium potentiometric titration experiments at a constant pH of 6.7 at 20 degrees C. The results confirmed the successful stabilization of amorphous calcium oxalate II and III (ACOII and ACO III) nanoparticles formed after PNC in the presence of PAA and suggest the participation and stabilization of polymer-induced liquid-precursor (PILP) in the presence of PAA. We demonstrated that PAA stabilizes CaOx precursors with size in the range of 20-400 nm. PAA additive plays a key role in the in vitro crystallization of CaOx stabilizing multi-ion complexes in the pre-nucleation stage, thereby delaying the nucleation of ACO nanoparticles. Indeed, PAA additive favors the formation of more hydrated and soluble phase of ACO nanoparticles that are bound by electrostatic interactions to carboxylic acid groups of PAA during the post-nucleation stage. These findings may help to a better understanding of the pathological mineralization resulting in urolithiasis in mammals.es_ES
Patrocinadordc.description.sponsorshipChilean Agency for Research and Development (ANID) - Fondecyt 1171520 ACCDiS center, Fondap 15130011 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) 21181417 Spanish Government European Commission RTI2018-099565-B-I00 Junta de Andalucia RNM-179es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.uri*
Keywordsdc.subjectCalcium oxalatees_ES
Keywordsdc.subjectPre-nucleation clusterses_ES
Keywordsdc.subjectPoly(acrylic acid)es_ES
Keywordsdc.subjectAmorphous calcium oxalate (ACO)es_ES
Títulodc.titleStabilization of calcium oxalate precursors during the pre- and post-nucleation stages with poly(acrylic acid)es_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Indexationuchile.indexArtículo de publícación WoSes_ES

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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States