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Authordc.contributor.authorRíos, Javiera
Authordc.contributor.authorSequeida, Álvaro
Authordc.contributor.authorAlbornoz, Amelina
Authordc.contributor.authorBudini, Mauricio Fernando
Cita de ítemdc.identifier.citationFrontiers in Oncology February 2021 Volume 10 Article 614677es_ES
Abstractdc.description.abstractChaperone-mediated autophagy (CMA) represents a specific way of lysosomal protein degradation and contrary to macro and microautophagy is independent of vesicles formation. The role of CMA in different physiopathological processes has been studied for several years. In cancer, alterations of the CMA principal components, Hsc70 and Lamp2A protein and mRNA levels, have been described in malignant cells. However, changes in the expression levels of these CMA components are not always associated with changes in CMA activity and their biological significance must be carefully interpreted case by case. The objective of this review is to discuss whether altering the CMA activity, CMA substrates or CMA components is accurate to avoid cancer progression. In particular, this review will discuss about the evidences in which alterations CMA components Lamp2A and Hsc70 are associated or not with changes in CMA activity in different cancer types. This analysis will help to better understand the role of CMA activity in cancer and to elucidate whether CMA can be considered as target for therapeutics. Further, it will help to define whether the attention of the investigation should be focused on Lamp2A and Hsc70 because they can have an independent role in cancer progression beyond of their participation in altered CMA activity.es_ES
Patrocinadordc.description.sponsorshipCONICYT PIA ACT172066es_ES
Publisherdc.publisherFrontiers Media SAes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.uri*
Sourcedc.sourceFrontiers in Oncologyes_ES
Keywordsdc.subjectOncogenic proteines_ES
Keywordsdc.subjectTumor suppressores_ES
Keywordsdc.subjectCancer progressiones_ES
Títulodc.titleChaperone mediated autophagy substrates and components in canceres_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Indexationuchile.indexArtículo de publícación WoSes_ES
Indexationuchile.indexArtículo de publicación SCOPUSes_ES

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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States