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Authordc.contributor.authorOrtiz, Andrea C.
Authordc.contributor.authorYáñez, Osvaldo
Authordc.contributor.authorSalas Huenuleo, Edison Sebastián
Authordc.contributor.authorMorales Montecinos, Javier Octavio
Cita de ítemdc.identifier.citationPharmaceutics 2021, 13, 531es_ES
Abstractdc.description.abstractLipid nanocarriers have a great potential for improving the physicochemical characteristics and behavior of poorly water-soluble drugs, such as aqueous dispersibility and oral bioavailability. This investigation presents a novel nanostructured lipid carrier (NLC) based on a mixture of solid lipid glycerides, fatty acid esters of PEG 1500 (Gelucire(R) 44/14), and an oil mix composed of capric and caprylic triglycerides (Miglyol(R) 812). These NLCs were developed by a simple low-energy method based on melt emulsification to yield highly encapsulating and narrowly distributed nanoparticles (similar to 100 nm, PdI = 0.1, and zeta potential = similar to-10 mV). Rhodamine 123 was selected as a poorly water-soluble drug model and owing to its spectroscopic properties. The novel NLCs were characterized by dynamic light scattering (DLS), zeta potential, nanoparticle tracking analysis (NTA), transmission electron microscopy (TEM), differential scanning calorimetry (DSC), and colloidal stability. The drug release was determined through a dialysis bag and vertical Franzs' cells to provide insights about the methods' suitability, revealing similar performance regardless of their different fluid dynamics. Rhodamine 123 followed a characteristic biphasic release profile owing to the swelling of the hydrophilic polymer coating and diffusion process from the lipid core as revealed by the Korsmeyers-Peppas kinetic modeling. Moreover, to elucidate the formation and incorporation of Rhodamine 123 into the NLC core, several molecular dynamics simulations were conducted. The temperature was shown to be an important condition to improve the formation of the nanoparticles. In addition, the liquid lipid incorporation to the formulation forms nanoparticles with imperfect centers, in contrast to nanoparticles without it. Moreover, Miglyol(R) 812 improves hydrophobic molecule solubility. These results suggest the potential of novel NLC as a drug delivery system for poorly water-soluble drugs.es_ES
Patrocinadordc.description.sponsorshipRegular FONDECYT Project - Chilean National Agency for Research and Development (ANID) 1181689 ANID/PIA - Chilean National Agency for Research and Development (ANID) ACT192144 ANID/FONDAP - Chilean National Agency for Research and Development (ANID) 15130011 ANID/PCI - Chilean National Agency for Research and Development (ANID) REDI170653 National Doctoral Scholarships - Chilean National Agency for Research and Development (ANID) 21180654es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.uri*
Keywordsdc.subjectLipid nanoparticlees_ES
Keywordsdc.subjectLow-energy methodes_ES
Keywordsdc.subjectGelucire® 44/14es_ES
Keywordsdc.subjectDrug releasees_ES
Keywordsdc.subjectFranz’s cellses_ES
Keywordsdc.subjectMolecular dynamics simulationses_ES
Títulodc.titleDevelopment of a nanostructured lipid carrier (nlc) by a low-energy method, comparison of release kinetics and molecular dynamics simulationes_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Indexationuchile.indexArtículo de publícación WoSes_ES
Indexationuchile.indexArtículo de publicación SCOPUSes_ES

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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States