Author | dc.contributor.author | González Hormazábal, Patricio | |
Author | dc.contributor.author | Peláez, Diana | |
Author | dc.contributor.author | Musleh Katan, Maher Elías | |
Author | dc.contributor.author | Bustamante, Marco | |
Author | dc.contributor.author | Stambuk Mayorga, Juan Antonio | |
Author | dc.contributor.author | Pisano, Raúl | |
Author | dc.contributor.author | Valladares Hernández, Héctor | |
Author | dc.contributor.author | Lanzarini Sobrevía, Enrique Giovani | |
Author | dc.contributor.author | Chiong, Héctor | |
Author | dc.contributor.author | Suazo Sanhueza, José Lorenzo | |
Author | dc.contributor.author | Quiñones Sepúlveda, Luis Abel | |
Author | dc.contributor.author | Varela Figueroa, Nelson Miguel Edgardo | |
Author | dc.contributor.author | Castro, Gonzalo | |
Author | dc.contributor.author | Jara Sosa, Lilian Elena | |
Author | dc.contributor.author | Berger, Zoltan | |
Admission date | dc.date.accessioned | 2021-11-15T19:11:30Z | |
Available date | dc.date.available | 2021-11-15T19:11:30Z | |
Publication date | dc.date.issued | 2021 | |
Cita de ítem | dc.identifier.citation | Biol Res (2021) 54:13 | es_ES |
Identifier | dc.identifier.other | 10.1186/s40659-021-00336-4 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/182688 | |
Abstract | dc.description.abstract | BackgroundHelicobacter pylori is detected by pathogen recognition receptors including toll-like receptors (TLR) and nucleotide-binding oligomerization domain (NOD)-like receptors, eliciting an innate immune response against this bacteria. The aim of this study was to assess if polymorphisms of TLR2, TLR4, TLR5, NOD1 and NOD2 genes are associated with gastric cancer, in particular in individuals infected with H. pylori.ResultsA case-control study of 297 gastric cancer patients and 300 controls was performed to assess the association of 17 polymorphisms. Analyses performed under the allele model did not find association with gastric cancer. However, NOD1 rs2075820 (p.E266K) showed association with intestinal-type gastric cancer among H. pylori infected subjects (OR=2.69, 95% CI 1.41-5.13, p=0.0026). The association was not statistically significant in diffuse-type gastric cancer cases (OR = 1.26, 95% CI 0.63-2.52, p=0.51). When the analyses were performed in patients carrying H. pylori strains harboring the cag pathogenicity island (cagPAI), we noticed significant association with NOD1 rs2075820 (OR=4.90, 95% CI 1.80-3.36, p=0.0019), in particular for intestinal-type gastric cancer cases (OR=7.16, 95% CI 2.40-21.33, p=4.1x10(-4)) but not among diffuse-type gastric cancer cases (OR=3.39, 95% CI 1.13-0.10, p=0.03).ConclusionsNOD1 rs2075820 increases the risk of intestinal-type gastric cancer among individuals infected with H. pylori, particularly in those harboring the cagPAI. | es_ES |
Patrocinador | dc.description.sponsorship | Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT FONDECYT 1151015 | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | Sociedad de Biología de Chile | es_ES |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
Source | dc.source | Biological Research | es_ES |
Keywords | dc.subject | Gastric cancer | es_ES |
Keywords | dc.subject | Polymorphism | es_ES |
Keywords | dc.subject | Association study | es_ES |
Keywords | dc.subject | H. pylori | es_ES |
Keywords | dc.subject | NOD1 | es_ES |
Keywords | dc.subject | E266K | es_ES |
Título | dc.title | NOD1 rs2075820 (p.E266K) polymorphism is associated with gastric cancer among individuals infected with cagPAI-positive H. pylori | es_ES |
Document type | dc.type | Artículo de revista | es_ES |
dc.description.version | dc.description.version | Versión publicada - versión final del editor | es_ES |
dcterms.accessRights | dcterms.accessRights | Acceso abierto | es_ES |
Cataloguer | uchile.catalogador | crb | es_ES |
Indexation | uchile.index | Artículo de publícación WoS | es_ES |