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Authordc.contributor.authorWhite, Sarah J.
Authordc.contributor.authorGerber Pluss, Denise Verónica
Authordc.contributor.authorSánchez Hernández, Romina D.
Authordc.contributor.authorEfiannay, Anthonia
Authordc.contributor.authorChowdhury, Ishita
Authordc.contributor.authorPartington, Hannah
Authordc.contributor.authorMoss, Joanna F.
Cita de ítemdc.identifier.citationThe British Journal of Psychiatry (2021) 218, 28–34es_ES
Abstractdc.description.abstractBackground Research on women with the fragile-X premutation (FX-p) has been underrepresented within the field of behavioural phenotypes. Aims To understand whether the FX-p confers risk for autistic traits, depression and anxiety, independent of maternal status. Method In study 1, mothers of children with fragile-X syndrome (M-FXp; n = 51, mean age 43 years (s.d. = 5.80)) were compared with mothers of autistic children (M-ASD; n = 59, mean age 42 (s.d. = 5.80)), mothers of children with Smith-Magenis syndrome (M-SMS; n = 27, mean age 39 (s.d. = 7.20)) and mothers of typically developing children (M-TD; n = 44, mean age 40 (s.d. = 4.90)). In study 2, the M-FXp group were compared with non-mothers with the FX-p (NM-FXp; n = 17, mean age 32 (s.d. = 9.20)), typically developed non-mothers (NM-TD; n = 28, mean age 31 (s.d. = 6.80)) and the M-TD group. All participants completed an online survey, including measures of IQ, autistic traits, anxiety, depression and positive affect. Results In study 1: the M-FXp group reported more autistic traits than the M-TD group (P < 0.05, eta(2) = 0.046). Anxiety and parental stress were elevated in the M-FXp, M-SMS and M-ASD groups relative to the M-TD group (all P = 0.003, eta(2) = 0.079-0.322). In study 2: a main effect of premutation status indicated that women with the FX-p report elevated autistic traits and anxiety (P = 0.007, eta(2) = 0.055-0.060); this did not interact with maternal status. Conclusions The findings indicate that women with the FX-p show an increased risk for autistic traits and anxiety. This risk is specific to the presence of the FX-p and is not fully accounted for by maternal status or the stress of caring for children with neurodevelopmental disorders.es_ES
Patrocinadordc.description.sponsorshipRoyal Society of London European Commission DH150167es_ES
Publisherdc.publisherCambridge University Presses_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.uri*
Sourcedc.sourceThe British Journal of Psychiatryes_ES
Keywordsdc.subjectFragile-X premutationes_ES
Keywordsdc.subjectBroader autism phenotypees_ES
Keywordsdc.subjectAutistic characteristicses_ES
Títulodc.titleAutistic traits and mental health in women with the fragile-X premutation: maternal status versus genetic riskes_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Indexationuchile.indexArtículo de publícación WoSes_ES

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Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States