Impact of exercise training on the sarcopenia criteria in non-alcoholic fatty liver disease: a systematic review and meta-analysis
Author
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González, Andrea
Author
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Valero Breton, Mayalen
Author
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Huerta Salgado, Camila Francisca
Author
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Achiardi, Oscar
Author
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Simon, Felipe
Author
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Cabello Verrugio, Claudio Alejandro
Admission date
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2021-12-10T20:17:44Z
Available date
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2021-12-10T20:17:44Z
Publication date
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2021
Cita de ítem
dc.identifier.citation
Eur J Transl Myol 31 (1): 9630, 2021
es_ES
Identifier
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10.4081/ejtm.2021.9630
Identifier
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https://repositorio.uchile.cl/handle/2250/183159
Abstract
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Sarcopenia is a highly prevalent complication of non-alcoholic fatty liver disease (NAFLD). We aimed to conduct a systematic review and meta-analyses to elucidate the exercise training (ET)'s efficacy on NAFLD adult patients' sarcopenia criteria. We identified relevant randomized controlled trials (RCT) in electronic databases PubMed, CINAHL, and Scopus. We selected seven RCT from 66 screened studies. The ET programs included endurance or combined (endurance and resistance) training. No study performed resistance training alone. The physical function improved with endurance or combined training (mean differences [MD] 8.26 mL/Kg*min [95% CI 5.27 to 11.24 mL/Kg*min], p < 0.0001); Muscle mass showed no evidence of the beneficial effects of endurance or combined training (MD 1.01 Kg [95% CI -1.78 to 3.80 Kg], p = 0.48). None of the selected studies evaluated muscle strength. Endurance and combined training increase physical function criteria but do not improve muscle mass criteria on sarcopenia in NAFLD patients. These results must be interpreted with caution for the small number of patients included in the RCTs analyzed, the different characteristics of the ET carried out, the non-use of resistance training, which prevents assess its effect on sarcopenia despite the evidence that recommends it and does not assessment muscle strength criteria in RCT include. Future research should include muscle strength assessments and resistance training to evaluate the effects in this condition. Exercise training is beneficial for sarcopenia in NAFLD but is necessary more experimental evidence to define the best type of training that positively affects the three criteria of sarcopenia.
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Patrocinador
dc.description.sponsorship
National Fund for Science and Technological Development FONDECYT 1200944
1201039
Millennium Institute on Immunology and Immunotherapy P09-016-F
BASAL Grant - CEDENNA from the National Research and Development Agency (ANID), Government of Chile AFB180001
Iniciativa Cientifica Milenio (ANID, Chile)
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Lenguage
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en
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Publisher
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Pagepress
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Type of license
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Attribution-NonCommercial-NoDerivs 3.0 United States