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Authordc.contributor.authorMüller, Bettina
Authordc.contributor.authorGarcía, Carlos
Authordc.contributor.authorSola Aylwin, José Antonio
Authordc.contributor.authorFernández, Wanda
Authordc.contributor.authorWerner, Patrick
Authordc.contributor.authorCerda, Mauricio
Authordc.contributor.authorSlater Morales, Jeannei Ann
Authordc.contributor.authorBenavides, Carlos
Authordc.contributor.authorArancibia, Jorge
Authordc.contributor.authorAscui Fernandez, Rodrigo Andres
Authordc.contributor.authorReyes, Felipe
Authordc.contributor.authorStevens Pinochet, Mary Ann
Authordc.contributor.authorMiranda, Juan Pablo
Authordc.contributor.authorBuchholtz Fontova, Martin Lucas
Authordc.contributor.authorCorvalán, Alejandro H
Admission datedc.date.accessioned2022-01-10T21:34:40Z
Available datedc.date.available2022-01-10T21:34:40Z
Publication datedc.date.issued2021
Cita de ítemdc.identifier.citationEcancer 2021, 15:1244es_ES
Identifierdc.identifier.other10.3332/ecancer.2021.1244
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/183651
Abstractdc.description.abstractGastric cancer (GC) is a leading cause of cancer death in Chile. Although recommended in international guidelines since 2006, perioperative chemotherapy was not available to patients in the public health system in Chile until 2016. We conducted an observational study to assess the feasibility of this strategy in public hospitals in Chile (Observational Study of Perioperative Chemotherapy in Locally Advanced Gastric Cancer – PRECISO). Patients with locally advanced, operable GC were offered to receive preoperative chemotherapy with Epirubicin + Cisplatin + Capecitabine (ECX) for three cycles followed by curative surgery. Staging included abdominal CT scan and laparoscopy if peritoneal carcinomatosis was suspected. Postoperative ECX for three cycles was recommended. Between August 2010 and March 2013, 110 patients were screened and 61 enrolled. Median age was 62 years (23–76 years) and most patients had good performance status at baseline (Eastern Cooperative Oncology Group performance status score (ECOG) 0: 42, ECOG 1: 19). Tumour site was proximal in 32 (52%) and medial and distal in 29 (48%) patients. All but four patients (n = 57, 93%) completed three cycles of preoperative chemotherapy. Fifty-six patients were operated and 54 (89%) had a curative resection. Thirty-three patients (54%) had pT0-2, and 18 (30%) had pN0 tumours, with two patients achieving a complete response. As of 20 December 2020, 39 patients died, 32 due to GC, one within 30 days of surgery, two due to intestinal obstruction at 5 and 3 months after surgery and four due to other causes. Five-year survival rate was 38%. We conclude that perioperative chemotherapy is feasible in public hospitals in Chile and should be offered to patients with locally advanced GC.es_ES
Patrocinadordc.description.sponsorshipNational Agency for Research and Development ICN09_015 PIA/ACT192015 Corporacion de Fomento de la Produccion (CORFO) 16CTTS-66390 Deutscher Akademischer Austausch Dienst (DAAD) 57220037 57168868 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDAP 1513001 Fondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT) from the National Agency for Research and Development (ANID), Government of Chile 1191928es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherCancer Intelligence Ltdes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
Sourcedc.sourceEcancer medical sciencees_ES
Keywordsdc.subjectStomach neoplasmses_ES
Keywordsdc.subjectSurvival ratees_ES
Keywordsdc.subjectLaparoscopyes_ES
Keywordsdc.subjectPublic healthes_ES
Keywordsdc.subjectFeasibility studieses_ES
Títulodc.titlePerioperative chemotherapy in locally advanced gastric cancer in Chile: from evidence to daily practicees_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Catalogueruchile.catalogadorcfres_ES
Indexationuchile.indexArtículo de publícación WoSes_ES


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States