Author | dc.contributor.author | Prusakov, Pavel | |
Author | dc.contributor.author | Goff, Debra A. | |
Author | dc.contributor.author | Wozniak, Phillip S. | |
Author | dc.contributor.author | Cassim, Azraa | |
Author | dc.contributor.author | Scipion, Catherine E. A. | |
Author | dc.contributor.author | Urzúa, Soledad | |
Author | dc.contributor.author | Ronchi, Andrea | |
Author | dc.contributor.author | Zeng, Lingkong | |
Author | dc.contributor.author | Ladipo Ajayi, Oluwaseun | |
Author | dc.contributor.author | Avilés Otero, Noelia | |
Author | dc.contributor.author | Udeigwe Okeke, Chisom R. | |
Author | dc.contributor.author | Melamed, Rimma | |
Author | dc.contributor.author | Silveira, Rita C. | |
Author | dc.contributor.author | Auriti, Cinzia | |
Author | dc.contributor.author | Beltrán Arroyave, Claudia | |
Author | dc.contributor.author | Zamora Flores, Elena | |
Author | dc.contributor.author | Sánchez Codez, María | |
Author | dc.contributor.author | Donkor, Eric S. | |
Author | dc.contributor.author | Kekomäki, Satu | |
Author | dc.contributor.author | Mainini, Nicoletta | |
Author | dc.contributor.author | Vivas Trochez, Rosalba | |
Author | dc.contributor.author | Casey, Jamalyn | |
Author | dc.contributor.author | Graus, Juan M. | |
Author | dc.contributor.author | Muller, Mallory | |
Author | dc.contributor.author | Singh, Sara | |
Author | dc.contributor.author | Loeffen, Yvette | |
Author | dc.contributor.author | Tamayo Pérez, María Eulalia | |
Author | dc.contributor.author | Ferreyra, Gloria Isabel | |
Author | dc.contributor.author | Lima Rogel, Victoria | |
Author | dc.contributor.author | Perrone, Bárbara | |
Author | dc.contributor.author | Izquierdo Copiz, Giannina | |
Author | dc.contributor.author | Cernada, María | |
Author | dc.contributor.author | Stoffella, Sylvia | |
Author | dc.contributor.author | Okwuchukwu Ekenze, Sebastián | |
Author | dc.contributor.author | Alba Romero, Concepción de | |
Author | dc.contributor.author | Tzialla, Chryssoula | |
Author | dc.contributor.author | Pham, Jennifer T. | |
Author | dc.contributor.author | Hosoi, Kenichiro | |
Author | dc.contributor.author | Calero Consuegra, Magdalena Cecilia | |
Author | dc.contributor.author | Betta, Pasqua | |
Author | dc.contributor.author | Hoyos, O. ALvaro | |
Author | dc.contributor.author | Roilides, Emmanuel | |
Author | dc.contributor.author | Naranjo Zúñiga, Gabriela | |
Author | dc.contributor.author | Oshiro, Makoto | |
Author | dc.contributor.author | Garay, Víctor | |
Author | dc.contributor.author | Mondì, Vito | |
Author | dc.contributor.author | Mazzeo, Danila | |
Author | dc.contributor.author | Stahl, James A. | |
Author | dc.contributor.author | Cantey, Joseph B. | |
Author | dc.contributor.author | Mesa Monsalve, Juan Gonzalo | |
Author | dc.contributor.author | Normann, Erik | |
Author | dc.contributor.author | Landgrave, Lindsay C. | |
Author | dc.contributor.author | Mazouri, Ali | |
Author | dc.contributor.author | Alarcón Ávila, Claudia | |
Author | dc.contributor.author | Piersigilli, Fiammetta | |
Author | dc.contributor.author | Trujillo, Mónica | |
Author | dc.contributor.author | Kolman, Sonya | |
Author | dc.contributor.author | Delgado, Verónica | |
Author | dc.contributor.author | Guzmán, Verónica | |
Author | dc.contributor.author | Abdellatif, Mohamed | |
Author | dc.contributor.author | Monterrosa, Luis | |
Author | dc.contributor.author | Gabriella Tina, Lucia | |
Author | dc.contributor.author | Yunis, Khalid | |
Author | dc.contributor.author | Belzu Rodríguez, Marco Antonio | |
Author | dc.contributor.author | Le Saux, Nicole | |
Author | dc.contributor.author | Leonardi, Valentina | |
Author | dc.contributor.author | Porta, Alessandro | |
Author | dc.contributor.author | Latorre, Giuseppe | |
Author | dc.contributor.author | Nakanishi, Hidehiko | |
Author | dc.contributor.author | Meir, Michal | |
Author | dc.contributor.author | Manzoni, Paolo | |
Author | dc.contributor.author | Norero, Ximena | |
Author | dc.contributor.author | Hoyos, Ángela | |
Author | dc.contributor.author | Arias, Diana | |
Author | dc.contributor.author | García Sánchez, Rubén | |
Author | dc.contributor.author | Medoro, Alexandra K. | |
Author | dc.contributor.author | Sánchez, Pablo J. | |
Admission date | dc.date.accessioned | 2022-03-15T19:47:35Z | |
Available date | dc.date.available | 2022-03-15T19:47:35Z | |
Publication date | dc.date.issued | 2021 | |
Cita de ítem | dc.identifier.citation | EClinicalMedicine 32 (2021) 100727 | es_ES |
Identifier | dc.identifier.other | 10.1016/j.eclinm.2021.100727 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/184203 | |
Abstract | dc.description.abstract | Background: Global assessment of antimicrobial agents prescribed to infants in the neonatal intensive care
unit (NICU) may inform antimicrobial stewardship efforts.
Methods: We conducted a one-day global point prevalence study of all antimicrobials provided to NICU
infants. Demographic, clinical, and microbiologic data were obtained including NICU level, census, birth
weight, gestational/chronologic age, diagnoses, antimicrobial therapy (reason for use; length of therapy),
antimicrobial stewardship program (ASP), and 30-day in-hospital mortality.
Findings: On July 1, 2019, 26% of infants (580/2,265; range, 0 100%; median gestational age, 33 weeks;
median birth weight, 1800 g) in 84 NICUs (51, high-income; 33, low-to-middle income) from 29 countries
(14, high-income; 15, low-to-middle income) in five continents received 1 antimicrobial agent (92%, antibacterial;
19%, antifungal; 4%, antiviral). The most common reasons for antibiotic therapy were “rule-out”
sepsis (32%) and “culture-negative” sepsis (16%) with ampicillin (40%), gentamicin (35%), amikacin (19%),
vancomycin (15%), and meropenem (9%) used most frequently. For definitive treatment of presumed/confirmed
infection, vancomycin (26%), amikacin (20%), and meropenem (16%) were the most prescribed agents.
Length of therapy for culture-positive and “culture-negative” infections was 12 days (median; IQR, 8 14)
and 7 days (median; IQR, 5 10), respectively. Mortality was 6% (42%, infection-related). An NICU ASP was
associated with lower rate of antibiotic utilization (p = 0¢02).
Interpretation: Global NICU antibiotic use was frequent and prolonged regardless of culture results. NICU-specific
ASPs were associated with lower antibiotic utilization rates, suggesting the need for their implementation
worldwide. | es_ES |
Patrocinador | dc.description.sponsorship | Merck & Company
Ohio State University College of Medicine Barnes Medical Student Research Scholarship | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | Elsevier | es_ES |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
Source | dc.source | EClinicalMedicine | es_ES |
Keywords | dc.subject | Global point prevalence study | es_ES |
Keywords | dc.subject | Neonatal infection | es_ES |
Keywords | dc.subject | Neonatal antimicrobial stewardship | es_ES |
Keywords | dc.subject | Antibiotics | es_ES |
Keywords | dc.subject | Antifunga | es_ES |
Título | dc.title | A global point prevalence survey of antimicrobial use in neonatal intensive care units: The no-more-antibiotics and Resistance (NO-MAS-R) study | es_ES |
Document type | dc.type | Artículo de revista | es_ES |
dc.description.version | dc.description.version | Versión publicada - versión final del editor | es_ES |
dcterms.accessRights | dcterms.accessRights | Acceso abierto | es_ES |
Cataloguer | uchile.catalogador | cfr | es_ES |
Indexation | uchile.index | Artículo de publícación WoS | es_ES |
Indexation | uchile.index | Artículo de publicación SCOPUS | es_ES |