Author | dc.contributor.author | Meyts, Isabelle | |
Author | dc.contributor.author | Bucciol, Giorgia | |
Author | dc.contributor.author | Quinti, Isabella | |
Author | dc.contributor.author | Neven, Bénédicte | |
Author | dc.contributor.author | Fischer, Alain | |
Author | dc.contributor.author | Seoane, Elena | |
Author | dc.contributor.author | López Granados, Eduardo | |
Author | dc.contributor.author | Gianelli, Carla | |
Author | dc.contributor.author | Robles Marhuenda, Ángel | |
Author | dc.contributor.author | Jeandel, Pierre-Yves | |
Author | dc.contributor.author | Paillard, Catherine | |
Author | dc.contributor.author | Sankaran, Vijay G. | |
Author | dc.contributor.author | Demirdag, Yesim Yilmaz | |
Author | dc.contributor.author | Lougaris, Vassilios | |
Author | dc.contributor.author | Aiuti, Alessandro | |
Author | dc.contributor.author | Plebani, Alessandro | |
Author | dc.contributor.author | Milito, Cinzia | |
Author | dc.contributor.author | Dalm, Virgil ASH | |
Author | dc.contributor.author | Guevara Hoyer, Kissy | |
Author | dc.contributor.author | Sánchez Ramón, Silvia | |
Author | dc.contributor.author | Bezrodnik, Liliana | |
Author | dc.contributor.author | Barzaghi, Federica | |
Author | dc.contributor.author | González Granado, Luis Ignacio | |
Author | dc.contributor.author | Hayman, Grant R. | |
Author | dc.contributor.author | Uzel, Gulbu | |
Author | dc.contributor.author | Oliveira Mendonca, Leonardo | |
Author | dc.contributor.author | Agostini, Carlo | |
Author | dc.contributor.author | Spadaro, Giuseppe | |
Author | dc.contributor.author | Badolato, Raffaele | |
Author | dc.contributor.author | Soresina, Annarosa | |
Author | dc.contributor.author | Vermeulen, François | |
Author | dc.contributor.author | Bosteels, Cedric | |
Author | dc.contributor.author | Lambrecht, Bart N. | |
Author | dc.contributor.author | Keller, Michael | |
Author | dc.contributor.author | Mustillo, Peter J. | |
Author | dc.contributor.author | Abraham, Roshini S. | |
Author | dc.contributor.author | Gupta, Sudhir | |
Author | dc.contributor.author | Ozen, Ahmet | |
Author | dc.contributor.author | Karakoc Aydiner, Elif | |
Author | dc.contributor.author | Baris, Safa | |
Author | dc.contributor.author | Freeman, Alexandra F. | |
Author | dc.contributor.author | Yamazaki Nakashimada, Marco | |
Author | dc.contributor.author | Scheffler Mendoza, Selma | |
Author | dc.contributor.author | Espinosa Padilla, Sara | |
Author | dc.contributor.author | Gennery, Andrew R. | |
Author | dc.contributor.author | Jolles, Stephen | |
Author | dc.contributor.author | Espinosa Vielma, Yazmin Paulina | |
Author | dc.contributor.author | Poli Harlowe, María Cecilia | |
Author | dc.contributor.author | Fieschi, Claire | |
Author | dc.contributor.author | Hauck, Fabian | |
Author | dc.contributor.author | Cunningham Rundles, Charlotte | |
Author | dc.contributor.author | Mahlaoui, Nizar | |
Author | dc.contributor.author | Warnatz, Klaus | |
Author | dc.contributor.author | Sullivan, Kathleen E. | |
Author | dc.contributor.author | Tangye, Stuart G. | |
Admission date | dc.date.accessioned | 2022-03-23T18:46:25Z | |
Available date | dc.date.available | 2022-03-23T18:46:25Z | |
Publication date | dc.date.issued | 2021 | |
Cita de ítem | dc.identifier.citation | J Allergy Clin Immunol Volume 147, Number 2 | es_ES |
Identifier | dc.identifier.other | 10.1016/j.jaci.2020.09.010 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/184400 | |
Abstract | dc.description.abstract | Background: There is uncertainty about the impact of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
infection in individuals with rare inborn errors of immunity
(IEI), a population at risk of developing severe coronavirus
disease 2019. This is relevant not only for these patients but also
for the general population, because studies of IEIs can unveil
key requirements for host defense.
Objective: We sought to describe the presentation,
manifestations, and outcome of SARS-CoV-2 infection in IEI to
inform physicians and enhance understanding of host defense
against SARS-CoV-2.
Methods: An invitation to participate in a retrospective study
was distributed globally to scientific, medical, and patient
societies involved in the care and advocacy for patients with IEI.
Results: We gathered information on 94 patients with IEI
with SARS-CoV-2 infection. Their median age was 25 to 34
years. Fifty-three patients (56%) suffered from primary
antibody deficiency, 9 (9.6%) had immune dysregulation
syndrome, 6 (6.4%) a phagocyte defect, 7 (7.4%) an
autoinflammatory disorder, 14 (15%) a combined
immunodeficiency, 3 (3%) an innate immune defect, and 2
(2%) bone marrow failure. Ten were asymptomatic, 25 were
treated as outpatients, 28 required admission without
intensive care or ventilation, 13 required noninvasive
ventilation or oxygen administration, 18 were admitted to
intensive care units, 12 required invasive ventilation, and 3
required extracorporeal membrane oxygenation. Nine patients
(7 adults and 2 children) died.
Conclusions: This study demonstrates that (1) more than 30%
of patients with IEI had mild coronavirus disease 2019 (COVID-
19) and (2) risk factors predisposing to severe disease/mortality
in the general population also seemed to affect patients with IEI,
including more younger patients. Further studies will identify
pathways that are associated with increased risk of severe
disease and are nonredundant or redundant for protection
against SARS-CoV-2. | es_ES |
Patrocinador | dc.description.sponsorship | FWO GCG0C8517N
VIB Grand Challenges PID
FWO
National Health and Medical Research Council of Australia
UNSW Sydney | es_ES |
Lenguage | dc.language.iso | en | es_ES |
Publisher | dc.publisher | Mosby-Elsevier | es_ES |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
Source | dc.source | Journal of Allergy and Clinical Immunology | es_ES |
Keywords | dc.subject | SARS-CoV-2 | es_ES |
Keywords | dc.subject | Primary immunodeficiencies | es_ES |
Keywords | dc.subject | Inborn errors of immunity | es_ES |
Keywords | dc.subject | Hypogammaglobulinemia | es_ES |
Keywords | dc.subject | Immune dysregulation | es_ES |
Keywords | dc.subject | COVID-19 (Enfermedad) | es_ES |
Título | dc.title | Coronavirus disease 2019 in patients with inborn errors of immunity: An international study | es_ES |
Document type | dc.type | Artículo de revista | es_ES |
dc.description.version | dc.description.version | Versión publicada - versión final del editor | es_ES |
dcterms.accessRights | dcterms.accessRights | Acceso abierto | es_ES |
Cataloguer | uchile.catalogador | cfr | es_ES |
Indexation | uchile.index | Artículo de publícación WoS | es_ES |