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Authordc.contributor.authorOliva Guerrero, Carolina
Authordc.contributor.authorCarrillo Beltrán, Diego
Authordc.contributor.authorBoettiger Bonnefoy, Paul
Authordc.contributor.authorGallegos Méndez, Iván
Authordc.contributor.authorAguayo González, Francisco
Admission datedc.date.accessioned2022-07-18T19:23:19Z
Available datedc.date.available2022-07-18T19:23:19Z
Publication datedc.date.issued2022
Cita de ítemdc.identifier.citationViruses 2022, 14, 1212.es_ES
Identifierdc.identifier.other10.3390/v14061212
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/186808
Abstractdc.description.abstractHigh-risk human papillomaviruses (HR-HPV) are the causal agents of an important subset of oropharyngeal cancers that has increased considerably in incidence in recent years. In this study, we evaluated the presence of HPV in 49 oropharyngeal cancers from Chilean subjects. The presence of HPV DNA was analyzed by conventional PCR, the genotypes were identified through sequencing, and the expression of E6/E7 transcripts was evaluated by a reverse transcriptase polymerase chain reaction (RT-PCR). Additionally, to determine p16 expression-a surrogate marker for oncogenic HPV infection-a tissue array was constructed for immunohistochemistry (IHC). HPV was detected in 61.2% of oropharyngeal carcinomas, the most prevalent genotype being HPV16 (80%). E6 and E7 transcripts were detected in 91.6% and 79.1% of the HPV16-positive specimens, respectively, demonstrating functional HPV infections. Furthermore, p16 expression was positive in 58.3% of cases. These findings show a high prevalence of HR-HPV in oropharyngeal tumors from Chile, suggesting the necessity of additional studies to address this growing public health concern.es_ES
Patrocinadordc.description.sponsorshipChilean Society of Otorhinolaryngology 21181116 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDECYT 1161219 1221033 Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT) CONICYT FONDAP 15130011es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherMDPIes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
Sourcedc.sourceViruseses_ES
Keywordsdc.subjectOropharyngeal canceres_ES
Keywordsdc.subjectHuman papillomaviruses_ES
Keywordsdc.subjectHead and neckes_ES
Keywordsdc.subjectSquamous cell carcinomas (OPSCC)es_ES
Títulodc.titleHuman papillomavirus detected in oropharyngeal cancers from chilean subjectses_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Catalogueruchile.catalogadorapces_ES
Indexationuchile.indexArtículo de publícación WoSes_ES


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States