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Authordc.contributor.authorLópez-Portillo García, María de Lourdes
Authordc.contributor.authorHuidobro, Andrea
Authordc.contributor.authorTobar Calfucoy, Eduardo Andrés
Authordc.contributor.authorYañez, Cristián
Authordc.contributor.authorRetamales Ortega, Rocío Mariana
Authordc.contributor.authorGarrido Tapia, Macarena
Authordc.contributor.authorAcevedo, Johanna
Authordc.contributor.authorParedes, Fabio
Authordc.contributor.authorCid Ossandón, Vicente
Authordc.contributor.authorFerreccio, Catterina
Authordc.contributor.authorVerdugo Salgado, Ricardo Alejandro
Admission datedc.date.accessioned2022-12-01T19:49:59Z
Available datedc.date.available2022-12-01T19:49:59Z
Publication datedc.date.issued2022
Cita de ítemdc.identifier.citationNutrients 2022, 14, 69es_ES
Identifierdc.identifier.other10.3390/nu14010069
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/189558
Abstractdc.description.abstractChile is one of the largest consumers of sugar-sweetened beverages (SSB) world-wide. However, it is unknown whether the effects from this highly industrialized food will mimic those reported in industrialized countries or whether they will be modified by local lifestyle or population genetics. Our goal is to evaluate the interaction effect between SSB intake and T2D susceptibility on fasting glucose. We calculated a weighted genetic risk score (GRSw) based on 16 T2D risk SNPs in 2828 non-diabetic participants of the MAUCO cohort. SSB intake was categorized in four levels using a food frequency questionnaire. Log-fasting glucose was regressed on SSB and GRSw tertiles while accounting for socio-demography, lifestyle, obesity, and Amerindian ancestry. Fasting glucose increased systematically per unit of GRSw (beta = 0.02 +/- 0.006, p = 0.00002) and by SSB intake (beta[cat4] = 0.04 +/- 0.01, p = 0.0001), showing a significant interaction, where the strongest effect was observed in the highest GRSw-tertile and in the highest SSB consumption category (beta = 0.05 +/- 0.02, p = 0.02). SNP-wise, SSB interacted with additive effects of rs7903146 (TCF7L2) (beta = 0.05 +/- 0.01, p = 0.002) and with the G/G genotype of rs10830963 (MTNRB1B) (beta = 0.19 +/- 0.05, p = 0.001). Conclusions: The association between SSB intake and fasting glucose in the Chilean population without diabetes is modified by T2D genetic susceptibility.es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherMDPIes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
Sourcedc.sourceNutrientses_ES
Keywordsdc.subjectSugar-sweetened beverageses_ES
Keywordsdc.subjectFasting glucosees_ES
Keywordsdc.subjectGenetic risk scorees_ES
Keywordsdc.subjectType 2 diabetes mellituses_ES
Keywordsdc.subjectNutritional epidemiologyes_ES
Keywordsdc.subjectGenotype by environment interactiones_ES
Keywordsdc.subjectLatin american ancestryes_ES
Títulodc.titleThe Association between fasting glucose and sugar sweetened beverages intake is greater in latin americans with a high polygenic risk score for type 2 diabetes mellituses_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Catalogueruchile.catalogadorapces_ES
Indexationuchile.indexArtículo de publícación WoSes_ES


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States