Mapping pediatric oncology clinical trial collaborative groups on the global stage
Author
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Major, Ajay
Author
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Palese, Mónica
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Ermis, Ebru
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James, Anthony
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Villarroel Cickovic, Milena
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Klussmann, Federico Antillon
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Hessissen, Laila
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Geel, Jennifer
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Khan, Muhammad Saghir
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Dalvi, Rashmi
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Sullivan, Michael
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Kearns, Pamela
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Frazier, Lindsay
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Pritchard Jones, Kathy
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Nakagawara, Akira
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Rodríguez Galindo, Carlos
Author
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Volchenboum, Samuel L.
Admission date
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2022-12-20T17:33:15Z
Available date
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2022-12-20T17:33:15Z
Publication date
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2022
Cita de ítem
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JCO Global Oncology (2022) 8: e2100266
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Identifier
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10.1200/GO.21.00266
Identifier
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https://repositorio.uchile.cl/handle/2250/189876
Abstract
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The global pediatric oncology clinical research landscape, particularly in Central and South America, Africa, and Asia, which bear the highest burden of global childhood cancer cases, is less characterized in the literature. Review of how existing pediatric cancer clinical trial groups internationally have been formed and how their research goals have been pursued is critical for building global collaborative research and data-sharing efforts, in line with the WHO Global Initiative for Childhood Cancer.
METHODS A narrative literature review of collaborative groups performing pediatric cancer clinical research in each continent was conducted. An inventory of research groups was assembled and reviewed by current pediatric cancer regional and continental leaders. Each group was narratively described with identification of common structural and research themes among consortia.
RESULTS There is wide variability in the structure, history, and goals of pediatric cancer clinical trial collaborative groups internationally. Several continental regions have longstanding endogenously-formed clinical trial groups that have developed and published numerous adapted treatment regimens to improve outcomes, whereas other regions have consortia focused on developing foundational database registry infrastructure supported by large multinational organizations or twinning relationships.
CONCLUSION There cannot be a one-size-fits-all approach to increasing collaboration between international pediatric cancer clinical trial groups, as this requires a nuanced understanding of local stakeholders and resources necessary to form partnerships. Needs assessments, performed either by local consortia or in conjunction with international partners, have generated productive clinical trial infrastructure. To achieve the goals of the Global Initiative for Childhood Cancer, global partnerships must be sufficiently granular to account for the distinct needs of each collaborating group and should incorporate grassroots approaches, robust twinning relationships, and implementation science.
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Patrocinador
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Children's Research Foundation
Comer Development Board
Leukemia and Lymphoma Society
Andrew McDonough B + Foundation
Neuroblastoma Children's Cancer Society
Rally Foundation for Childhood Cancer Research
Sammy's Superheroes
St Baldrick's Foundation
The Matthew Bittker Foundation
Team Bright Side
Children's Cancer Research Fund
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Lenguage
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en
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Publisher
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Lippincott Williams & Wilkins
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Type of license
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Attribution-NonCommercial-NoDerivs 3.0 United States