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Authordc.contributor.authorContreras, Esteban G.
Authordc.contributor.authorSierralta Jara, Jimena Alejandra
Admission datedc.date.accessioned2023-06-22T18:59:04Z
Available datedc.date.available2023-06-22T18:59:04Z
Publication datedc.date.issued2022
Cita de ítemdc.identifier.citationNeuroscience Insights Volume 17: 1–7 2022es_ES
Identifierdc.identifier.other10.1177/26331055221120252
Identifierdc.identifier.urihttps://repositorio.uchile.cl/handle/2250/194402
Abstractdc.description.abstractIn the wild, animals face different challenges including multiple events of food scarcity. How they overcome these conditions is essential for survival. Thus, adaptation mechanisms evolved to allow the development and survival of an organism during nutrient restriction periods. Given the high energy demand of the nervous system, the molecular mechanisms of adaptation to malnutrition are of great relevance to fuel the brain. The blood-brain barrier (BBB) is the interface between the central nervous system (CNS) and the circulatory system. The BBB mediates the transport of macromolecules in and out of the CNS, and therefore, it can buffer changes in nutrient availability. In this review, we collect the current evidence using the fruit fly, Drosophila melanogaster, as a model of the role of the BBB in the adaptation to starvation. We discuss the role of the Drosophila BBB during nutrient deprivation as a potential sensor for circulating nutrients, and transient nutrient storage as a regulator of the CNS neurogenic niche.es_ES
Patrocinadordc.description.sponsorshipANID Becas Chile 74200032 Comisión Nacional de Investigación Científica y Tecnológica (CONICYT) CONICYT FONDECYT 1210586es_ES
Lenguagedc.language.isoenes_ES
Publisherdc.publisherSAGEes_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/us/*
Sourcedc.sourceNeuroscience Insightses_ES
Keywordsdc.subjectDrosophila melanogasteres_ES
Keywordsdc.subjectBlood-brain barrieres_ES
Keywordsdc.subjectNutritiones_ES
Keywordsdc.subjectGlial cellses_ES
Títulodc.titleThe fly blood-brain barrier fights against nutritional stresses_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Catalogueruchile.catalogadorcfres_ES
Indexationuchile.indexArtículo de publícación WoSes_ES
Indexationuchile.indexArtículo de publicación SCOPUSes_ES


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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States