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Authordc.contributor.authorMugnaini, Matias
Authordc.contributor.authorPolania Caviedes, Diana Marcela
Authordc.contributor.authorDíaz, Yannina
Authordc.contributor.authorEzquer, Marcelo
Authordc.contributor.authorEzquer, Fernando
Authordc.contributor.authorDeacon, Robert M. J.
Authordc.contributor.authorCogram, Patricia
Authordc.contributor.authorKropf, Emilio
Cita de ítemdc.identifier.citationScientifc Reports (2022) 12:7350es_ES
Abstractdc.description.abstractThe Octodon degus is a South American rodent that is receiving increased attention as a potential model of aging and sporadic late-onset Alzheimer's disease (AD). Impairments in spatial memory tasks in Octodon degus have been reported in relation to either advanced AD-like disease or hippocampal lesion, opening the way to investigate how the function of hippocampal networks affects behavior across AD stages. However, no characterization of hippocampal electrophysiology exists in this species. Here we describe in young, healthy specimens the activity of neurons and local field potential rhythms during spatial navigation tasks with and without objects. Our findings show similarities between the Octodon degus and laboratory rodents. First, place cells with characteristics similar to those found in rats and mice exist in the CA1 subfield of the Octodon degus. Second, the introduction of objects elicits novelty-related exploration and an increase in activity of CA1 cells, with location specific and unspecific components. Third, oscillations of the local field potential are organized according to their spectral content into bands similar to those found in laboratory rodents. These results suggest a common framework of underlying mechanisms, opening the way to future studies of hippocampal dysfunction in this species associated to aging and disease.es_ES
Patrocinadordc.description.sponsorshipANID FONDECYT 1200928 United States Department of Health & Human Services National Institutes of Health (NIH) - USA R24AG073198 Science Ministry of Argentina PICT 2015-1273 PICT 2017-1160es_ES
Type of licensedc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
Link to Licensedc.rights.uri*
Sourcedc.sourceScientifc Reportses_ES
Keywordsdc.subjectTheta rhythimes_ES
Keywordsdc.subjectGrid cellses_ES
Keywordsdc.subjectObject recognitiones_ES
Keywordsdc.subjectEntorhinal cortexes_ES
Keywordsdc.subjectMemory deficitses_ES
Keywordsdc.subjectPlace cellses_ES
Títulodc.titleSpatial maps and oscillations in the healthy hippocampus of octodon degus, a natural model of sporadic Alzheimer’s diseasees_ES
Document typedc.typeArtículo de revistaes_ES
dc.description.versiondc.description.versionVersión publicada - versión final del editores_ES
dcterms.accessRightsdcterms.accessRightsAcceso abiertoes_ES
Indexationuchile.indexArtículo de publícación WoSes_ES

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Attribution-NonCommercial-NoDerivs 3.0 United States
Except where otherwise noted, this item's license is described as Attribution-NonCommercial-NoDerivs 3.0 United States