Repositorio Académico de la Universidad de Chile: Recent submissions

Now showing items 37101-37120 of 100307

    • Pharmacogenomics in psychiatric practice: Latin America initiatives 
      Ortiz L., Lina; Moreno, Mauricio; Quiñones Sepúlveda, Luis (Nova Science, 2017)
      Although pharmacogenomics has had a good development in most of medical specialties, in Psychiatry has been particularly successful. Thus, it is extremely useful in psychiatric patients, given how common is the use of ...
    • Future directions: challenges, opportunities and limitations 
      Redal, María A.; Quiñones Sepúlveda, Luis (Nova Science, 2017)
      The ultimate goal of pharmacogenomic research is to predict individual's responses to drug therapy and subsequently adapt pharmacotherapeutic strategies. Therefore, the current challenge for personalized therapy is to ...
    • The incorporation of clinical guidelines of pharmacogenomics in Latin America 
      Quiñones Sepúlveda, Luis; Lares Asseff, Ismael (Nova Science, 2017)
      In Latin America the Pharmacogenetics and Pharmacogenomics areas are recently emerging fields and the main focus of the research is to evaluate ethnic differences to apply adapted guidelines to manage personalized ...
    • Pharmacogenomics of antiretroviral therapy in Latin America 
      Varela Figueroa, Nelson; Bernal, Fernando (Nova Science, 2017)
      AIDS is caused by infection with human immunodeficiency virus (HIV), which when untreated produces a critical decline in CD4+ T cells, triggering a progressive dysfunction of the immune system and the development of ...
    • Chile's national center for health information systems: A public-private partnership to foster health care ... 
      Capurro, Daniel; Echeverry, Aisen; Figueroa, Rosa; Guiñez, Sergio; Taramasco, Carla; Galindo, César; Avendaño, Angélica; García, Alejandra; Hartel, Steffen (IOS, 2017)
      Despite the continuous technical advancements around health information standards, a critical component to their widespread adoption involves political agreement between a diverse set of stakeholders. Countries that ...
    • Assessment of automatically exported clinical data from a hospital information system for clinical research ... 
      Torres, Viviana; Cerda, Mauricio; Knaup, Petra; Löpprich, Martin (IOS, 2016)
      PURPOSE: An important part of the electronic information available in Hospital Information System (HIS) has the potential to be automatically exported to Electronic Data Capture (EDC) platforms for improving clinical ...
    • Cardiovascular pharmacogenomics: clinical applications in Latin America 
      Roco A., Ángela M.; Quiñones Sepúlveda, Luis; Miranda, Carla E. (Nova Science, 2017)
      Cardiovascular diseases (CVDs) are the number one cause of death globally. Most cardiovascular diseases can be prevented by addressing behavioral risk factors such as tobacco use, unhealthy diet and obesity, physical ...
    • Clinical pharmacogenomics in South America 
      Cayún, Juan P.; Miranda, Carla E.; Lavanderos, Alejandra; Martínez, Matías F.; Escalante, Paula I.; Suárez, Marcelo I.; Cerro, Roberto A.; Sandoval, Christopher A.; Cerpa, Leslie C.; Moreno, Paulina A. (Nova Science Publishers, Inc., 2017)
      © 2011 by Nova Science Publishers, Inc. All rights reserved.In South America, in recent years, some studies have established allelic frequencies of the most relevant pharmacogenes. Several studies in South America have ...
    • The interaction of aquatic organisms (Mytilus Sp.) with harmful algal blooms: Composition, distribution and ... 
      García, Carlos; Oyaneder Terrazas, Javiera; Figueroa, Diego; Díaz, Carolina; Mora, Romina; Contreras, Héctor R. (Nova Science, 2017)
      For years, marine resources have been an important part of human development due to the high nutritional contribution they possess. Mussels sp. are the most consumed species in the world. As a result of requirements and ...
    • Metabolic Syndrome and Mammographic Density in Premenopausal Chilean Women 
      Martínez Arroyo, Ángela; Moreno Macías, Hortensia; Pereira Scalabrino, Ana; Garmendia Miguel, María Luisa (Routledge, 2017)
      Background: Metabolic syndrome (MetS) has been previously associated with an increased risk of breast cancer in postmenopausal women. Mammographic density (MD) is a marker of breast cancer risk. There is little evidence ...
    • Expression of MYD88 in Adipose Tissue of Obese People: Is There Some Role in the Development of Metabolic Syndrome? 
      Cuevas, Ada M.; Lazo, Mariana; Zúñiga, Isabel; Carrasco, Fernando; Potter, Jim J.; Álvarez, Verónica; Berry, Marcos; Maluenda, Fernando; Ferrario, Mario; Clark, Jeanne M. (Mary Ann Liebert, 2017)
      BACKGROUND: The mechanism leading to the development of metabolic complications in obese individuals is not fully understood. Thus, the objective of this study was to examine differences in insulin resistance, inflammation, ...
    • Anthropometric indicators as predictors of total body fat and cardiometabolic risk factors in Chilean ... 
      Vásquez, F. D.; Corvalán Aguilar, Camila; Uauy Dagach-Imbarack, Ricardo; Kain Berkovic, Juliana (Nature, 2017)
      BACKGROUND/OBJECTIVE:To compare the association between anthropometric indicators of global and central obesity aspredictors of total body fat (TBF) and cardiometabolic risk factors in children.SUBJECTS/METHODS:A total of ...
    • Role of non-coding regulatory RNA in the virulence of human pathogenic vibrios 
      Pérez Reytor, Diliana; Plaza, Nicolás; Espejo, Romilio T.; Navarrete, Paola; Bastías, Roberto; García, Katherine (Frontiers Media, 2017)
      In recent decades, the identification of small non-coding RNAs in bacteria has revealed an important regulatory mechanism of gene expression involved in the response to environmental signals and to the control of virulence. ...
    • First-year metabolic control guidelines and their impact on future metabolic control and neurocognitive ... 
      Parra, Alicia de la; García, María Ignacia; Hamilton, Valerie; Arias Pefaur, Carolina; Cabello Andrade, Juan Francisco; Cornejo Espinoza, Verónica (Elsevier, 2017)
      There is a consensus on the importance of early and life-long treatment for PKU patients. Still, differences existon target blood phenylalanine (Phe) concentrations for children with PKU in different countries and ...
    • The human serum metabolome of vitamin B-12 deficiency and repletion, and associations with neurological ... 
      Brito, Álex; Grapov, Dmitry; Fahrmann, Johannes; Harvey, Danielle; Green, Ralph; Miller, Joshua W.; Fedosov, Sergey N.; Shahab-Ferdows, Setareh; Hampel, Daniela; Pedersen, Theresa L.; Fiehn, Oliver; Newman, John W.; Uauy Dagach-Imbarack, Ricardo; Allen, Lindsay H. (American Society for Nutrition, 2017)
      Background:The specific metabolomic perturbations that occur in vitamin B-12 deficiency, and their associations withneurological function, are not well characterized.Objective:We sought to characterize the human serum ...
    • Pompe disease: Clinical perspectives 
      Cabello Andrade, Juan Francisco; Marsden, Deborah (Dove Medical, 2017)
      Pompe disease (acid alpha-glucosidase deficiency, OMIM 232300) is a rare lysosomal storage disorder due to autosomal recessive mutations in the GAA gene. It has also been called acid maltase deficiency and glycogen storage ...
    • Glucose Promotes a Pro-Oxidant and Pro-Inflammatory Stromal Microenvironment Which Favors Motile Properties ... 
      Kallens, Violeta; Tobar Bachler, Nicolás; Molina, Jessica; Bidegain, Arantzazú; Smith, Patricio C.; Porras Espinoza, Omar; Martínez, Jorge (Wiley, 2017)
      Chronic inflammation and metabolic reprogramming have been proposed as hallmarks of cancer development. Currently, many of the functional clues between these two phenomena are studied under the integrative view of functional ...
    • Acute effect of iloprost inhalation on right atrial function and ventricular dyssynchrony in patients with ... 
      Gabrielli, Luigi; Ocaranza, María Paz; Sitges, Marta; Kanacri, Andrés; Saavedra, Rodrigo; Sepúlveda, Pablo; Sepúlveda, Luis; Rossel, Víctor; Zagolin, Mónica; Verdejo, Hugo E.; Baraona, Fernando; Zalaquett Sepúlveda, Ricardo; Chiong Lay, Mario; Lavandero González, Sergio; Castro, Pablo F. (Blackwell, 2017)
      Background: Right atrium function and ventricular function have significant prognos-tic value in pulmonary arterial hypertension patients. Acute changes in right ventricu-lar synchrony and right atrium function postiloprost ...
    • Predictors of gestational weight gain among chilean pregnant women: the chilean maternal and infant nutrition ... 
      Garmendia Miguel, María Luisa; Mondschein, Susana; Matus, Omar; Murrugarra, Ruth; Uauy Dagach-Imbarack, Ricardo (Taylor and Francis, 2017)
      We identified factors associated with gestational weight gain (GWG) in 1,654 Chilean pregnant women with full-term pregnancies. At baseline, we collected information about sociodemographic, gyneco-obstetric, anthropometric, ...
    • Spectral model for long-term computation of thermodynamics and potential evaporation in shallow wetlands 
      Fuente Stranger, Alberto de la; Meruane Naranjo, Carolina (Blackwell, 2017)
      Altiplanic wetlands are unique ecosystems located in the elevated plateaus of Chile, Argentina, Peru, and Bolivia. These ecosystems are under threat due to changes in land use, groundwater extractions, and climate change ...