Repositorio Académico de la Universidad de Chile: Recent submissions

Now showing items 40021-40040 of 101786

    • The signaling pathways underlying BDNF-induced Nrf2 hippocampal nuclear translocation involve ROS, RyR-Mediated ... 
      Bruna, Bárbara; Lobos, Pedro; Herrera Molina, Rodrigo; Hidalgo Tapia, María Cecilia; Paula Lima, Andrea; Adasme, Tatiana (Elsevier B.V., 2018)
      © 2018 Elsevier Inc. The neurotrophin Brain-Derived Neurotrophic Factor (BDNF) induces complex neuronal signaling cascades that are critical for the cellular changes underlying synaptic plasticity. These pathways include ...
    • Metformin prevents nerve growth factor-dependent proliferative and proangiogenic effects in epithelial ... 
      Garrido, Maritza P.; Vera, Carolina; Vega Blanco, María Margarita; Quest, Andrew F. G.; Romero Osses, Carmen (SAGE Publications Inc., 2018)
      © The Author(s), 2018. Background: Epithelial ovarian cancer (EOC) is characterized by exacerbated angiogenesis regulated by proangiogenic and growth factors. Nerve growth factor (NGF) is overexpressed in EOC where it ...
    • Echinococcus granulosus hydatid cyst location is modified by Fasciola hepatica infection in cattle 
      Stoore, Caroll; Andrade, Constanza; Hidalgo, Christian; Corrêa, Felipe; Jiménez, Mauricio; Hernandez, Marcela; Paredes, Rodolfo (BioMed Central Ltd., 2018)
      © 2018 The Author(s). Background: Natural parasite infection occurs in wild and domestics animals with more than one parasite species at the same time, generating an infection called polyparasitism. Cystic echinococcosis ...
    • Periodontitis and placental growth factor in oral fluids are early pregnancy predictors of gestational ... 
      Chaparro, Alejandra; Zúñiga, Edgardo; Varas-Godoy, Manuel; Albers, Daniela; Ramírez, Valeria; Hernández, Marcela; Kusanovic, Juan Pedro; Acuña-Gallardo, Stephanie; Rice, Gregory; Illanes, Sebastián E. (Wiley-Blackwell, 2018)
      © 2018 American Academy of Periodontology. Background: Gestational diabetes mellitus (GDM) affects around 7% to 10% of all pregnancies. Early detection of predisposition to GDM is the first step in developing efficacious ...
    • Hallazgo de una nueva mutación en una familia chilena con diabetes monogénica. Caso clínico 
      Estica R., Marcos; Seelenfreund H., Daniela; Durruty A., Pilar; Briones B., Gloria (Sociedad Medica de Santiago, 2018)
      We report a 21 years old woman, without offspring, with diabetes mellitus diagnosed at 17 years of age, without ketosis or weight loss. Her body mass index was 18 kg/m2. Her C peptide was normal (2.3 ng/ml) and diabetes ...
    • Interferon lambda 4 rs12979860 C>T polymorphism is not associated with liver fibrosis in patients with ... 
      Brahm Barril, Javier; Urzúa Manchego, Álvaro; Poniachik Teller, Jaime; Cáceres, Dante D.; Carreño, Laura; Luca Venegas, Mauricio Pascual de (Sociedad Medica de Santiago, 2018)
      © 2018, Sociedad Medica de Santiago. All rights reserved. Background. Host genetic predispositions may be important determinants of liver fibrosis in patients with chronic hepatitis C (CHC). The association between ...
    • Directed acyclic graphs in statistical modelling of epidemiological studies Aplicación de grafos acíclicos ... 
      Werlinger, Fabiola; Cáceres, Dante D. (Sociedad Medica de Santiago, 2018)
      © 2018, Sociedad Medica de Santiago. All rights reserved. Background: Confusion in observational epidemiological studies distorts the relationship between exposure and event. “Step by step” regression models, diverts the ...
    • Factors promoting vulnerability to dysregulated stress reactivity and stress-related disease 
      Russell, Ashley L.; Tasker, Jeffrey G.; Lucion, Aldo B.; Fiedler, Jenny; Munhoz, Carolina D.; Wu, Tao yiao John; Deak, Terrence (Blackwell Publishing Ltd, 2018)
      © 2018 British Society for Neuroendocrinology Effective coordination of the biological stress response is integral for the behavioural well-being of an organism. Stress reactivity is coordinated by an interplay of the ...
    • Fish intake, circulating mercury and mortality in renal transplant recipients 
      Sotomayor, Camilo G.; Gomes-Neto, António W.; Gans, Rijk O.B.; de Borst, Martin H.; Berger, Stefan P.; Rodrigo Salinas, Ramón; Navis, Gerjan J.; Touw, Daan J.; Bakker, Stephan J.L. (MDPI AG, 2018)
      © 2018 by the authors. Licensee MDPI, Basel, Switzerland. Marine-derived omega-3 polyunsaturated fatty acids (n-3 PUFAs) are inversely associated with cardiovascular and all-cause mortality in renal transplant recipients ...
    • ADAR1-mediated RNA-editing of 3'UTRs in breast cancer 
      Sagredo, Eduardo A.; Blanco, Alejandro; Sagredo, Alfredo I.; Pérez, Paola; Sepúlveda-Hermosilla, Gonzalo; Morales, Fernanda; Müller, Bettina; Verdugo, Ricardo; Marcelain Cubillos, Katherine; Harismendy, Olivier; Armisén, Ricardo (NLM (Medline), 2018)
      RESULTS: We characterized A to G(I) mRNA editing in 81 breast cell lines, showing increased editing at 3'UTR and exonic regions in breast cancer cells compared to immortalized non-malignant cell lines. In addition, tumors ...
    • Inverse association between estrogen receptor-α DNA methylation and breast composition in adolescent Chilean girls 
      Binder, Alexandra M.; Stiemsma, Leah T.; Keller, Kristen; Van Otterdijk, Sanne D.; Mericq, Verónica; Pereira, Ana; Santos, José Luis; Shepherd, John; Michels, Karin B. (BioMed Central Ltd., 2018)
      © 2018 The Author(s). Background: Estrogen receptor-α (ER-α) is a transcriptional regulator, which mediates estrogen-dependent breast development, as well as breast tumorigenesis. The influence of epigenetic regulation of ...
    • The activity of discrete sets of neurons in the posterior insula correlates with the behavioral expression ... 
      Casanova, José Patricio; Aguilar-Rivera, Marcelo; Rodríguez, María de los Ángeles; Coleman, Todd P.; Torrealba, Fernando (American Physiological Society, 2018)
      © 2018 American Physiological Society. All rights reserved. The interoceptive insular cortex is known to be involved in the perception of bodily states and emotions. Increasing evidence points to an additional role for the ...
    • Genetic contributors to serum uric acid levels in Mexicans and their effect on premature coronary artery disease 
      Macias-Kauffer, Luis R.; Villamil-Ramírez, Hugo; León-Mimila, Paola; Jacobo-Albavera, Leonor; Posadas-Romero, Carlos; Posadas-Sánchez, Rosalinda; López-Contreras, Blanca E.; Morán-Ramos, Sofía; Romero-Hidalgo, Sandra; Acuña Alonzo, Víctor; del-Río-Navarro, Blanca E (Elsevier Ireland Ltd, 2018)
      © 2018 Elsevier B.V.Background: Serum uric acid (SUA) is a heritable trait associated with cardiovascular risk factors and coronary artery disease (CAD). Genome wide association studies (GWAS) have identified several genes ...
    • Formation of massive iron deposits linked to explosive volcanic eruptions 
      Ovalle, J. Tomás; La Cruz, Nikita L.; Reich Morales, Martín; Barra, Fernando; Simon, Adam C.; Konecke, Brian A.; Rodriguez-Mustafa, María A.; Deditius, Artur P.; Childress, Tristan M.; Morata Céspedes, Diego (Nature Publishing Group, 2018)
      © 2018, The Author(s). The genetic link between magmas and ore deposit formation is well documented by studies of fossil hydrothermal systems associated with magmatic intrusions at depth. However, the role of explosive ...
    • FR58P1a; a new uncoupler of OXPHOS that inhibits migration in triple-negative breast cancer cells via ... 
      Urra, Félix A.; Hernández Muñoz, Felipe Andrés; Córdova Delgado, Miguel; Ramírez, María Paz; Peña Ahumada, Bárbara; Rios, Melany; Cruz, Pablo; Ahumada-Castro, Ulises; Bustos, Galdo; Silva-Pavez, Eduardo; Pulgar Tejo, Rodrigo; Morales, Danna; Varela, Diego; Millas-Vargas, Juan Pablo; Retamal (Nature Publishing Group, 2018)
      © 2018, The Author(s).Highly malignant triple-negative breast cancer (TNBC) cells rely mostly on glycolysis to maintain cellular homeostasis; however, mitochondria are still required for migration and metastasis. Taking ...
    • Biomarker responses of the freshwater clam Corbicula fluminea in acid mine drainage polluted systems 
      Bonnail, Estefanía; Cunha Lima, Ricardo; Bautista-Chamizo, Esther; Salamanca, María José; Cruz-Hernández, Pablo (Elsevier Ltd, 2018)
      © 2018 Elsevier Ltd The environmental quality of an acid mine drainage polluted river (Odiel River) in the Iberian Pyrite Belt (SW Spain) was assessed by combining analyses of biomarkers (DNA strand breaks, LPO, EROD, GST, ...
    • Prevention of stroke: a global perspective 
      Pandian, Jeyaraj D.; Gall, Seana L.; Kate, Mahesh P.; Silva, Gisele S.; Akinyemi, Rufus O.; Ovbiagele, Bruce I.; Lavados Germain, Pablo Manuel; Gandhi, Dorcas B.C.; Thrift, Amanda G. (Lancet Publishing Group, 2018)
      © 2018 Elsevier Ltd Along with the rising global burden of disability attributed to stroke, costs of stroke care are rising, providing the impetus to direct our research focus towards effective measures of stroke prevention. ...
    • IL-8-251T>A (rs4073) polymorphism is associated with prognosis in gastric cancer patients 
      González Hormazábal, Patricio; Romero, Sandra; Musleh, Maher; Bustamante, Marco; Stambuk, Juan; Pisano, Raul; Lanzarini, Enrique; Chiong, Hector; Rojas, Jorge; Castro, Victor Gonzalo; Jara, Lilian; Berger, Zoltan (International Institute of Anticancer Research, 2018)
      © 2018 International Institute of Anticancer Research. All rights reserved. Background/Aim: Inflammation is a key process in gastric carcinogenesis. Cytokines are mediators of inflammation and are involved in metastasis ...
    • Body mass index is negatively associated with telomere length: A collaborative cross-sectional meta-analysis ... 
      Gielen, Marij; Hageman, Geja J.; Antoniou, Evangelia E.; Nordfjall, Katarina; Mangino, Massimo; Balasubramanyam, Muthuswamy; De Meyer, Tim; Hendricks, Audrey E.; Giltay, Erik J.; Hunt, Steven C.; Nettleton, Jennifer A.; Salpea, Klelia D.; Diaz, Vanessa A.; Farzaneh-Fa (Oxford University Press, 2018)
      © 2018 American Society for Nutrition. Background: Even before the onset of age-related diseases, obesity might be a contributing factor to the cumulative burden of oxidative stress and chronic inflammation throughout the ...
    • Spinal cord infarction with ipsilateral segmental neuropathic pain and flaccid paralysis. A functional role ... 
      Campero, Mario; Hughes, Ricardo; Orellana, Patricia; Bevilacqua, Jorge; Guiloff, Roberto J. (Elsevier B.V., 2018)
      © 2018 This paper illustrates the cases of two patients with an acute onset of right brachial neuropathic pain, flaccid paralysis and contralateral thermal and thermal pain hypoesthesia, without posterior column impairment ...