Facultad de Ciencias Químicas y Farmacéuticas: Recent submissions

Now showing items 2801-2820 of 4850

    • Intramolecular hydrogen bond in biologically active o-carbonyl hydroquinones 
      Martínez Cifuentes, Maximiliano; Weiss López, Boris; Santos, Leonardo S.; Araya Maturana, Ramiro (MDPI, 2014)
      Intramolecular hydrogen bonds (IHBs) play a central role in the molecular structure, chemical reactivity and interactions of biologically active molecules. Here, we study the IHBs of seven related o-carbonyl hydroquinones ...
    • Electrooxidation of DNA at glassy carbon electrodes modified with multi-walled carbon nanotubes with different ... 
      Cañete Rosales, Paulina; Álvarez Lueje, Alejandro; Bollo Dragnic, Soledad (Sociedad Chilena de Química, 2014)
      For the first time, the study of the effect of length and degree of oxidation of multi-walled carbon nanotubes (CNTs) on the electroanalytical DNA sensing properties of modified glassy carbon electrodes (GCEs) is reported. ...
    • First report of in vitro selection of RNA aptamers targeted to recombinant Loxosceles laeta spider toxins 
      Sapag Muñoz de la Peña, Amalia; Salinas Luypaert, Catalina; Constenla Muñoz, Carlos (Sociedad de Biología de Chile, 2014)
      Background: Loxoscelism is the envenomation caused by the bite of Loxosceles spp. spiders. It entails severe necrotizing skin lesions, sometimes accompanied by systemic reactions and even death. There are no diagnostic means ...
    • Study by fluorescence of calix[4]arenes bearing heterocycles with divalent metals: highly selective detection ... 
      Quiroga Campano, Cinthia del Rosario; Gómez Machuca, Horacio Exequiel; Jullian Matthaei, Carolina; Fuente Urrutia, Julio de la; Pessoa Mahana, Hernán; Saitz Barría, Claudio (Springer, 2014)
      The present work describes a study of complexation efficiency and selectivity of calix[4]arenes bearing benzoimidazolyl, benzothiazolyl, and benzoxazolyl heterocycles (5–7) towards several selected metal ions ...
    • Synthesis and Biological Screening of Novel Indolalkyl Arenes Targeting the Serotonine Transporter 
      Ojeda Gómez, Claudia; Pessoa Mahana, Hernán; Iturriaga-Vásquez, Patricio; Pessoa Mahana, Carlos David; Recabarren Gajardo, Gonzalo Iván; Méndez Rojas, Claudio (Wiley, 2014)
      A series of functionalized indolylalkylarenes 3–16(a and b) were synthesized and their affinities for the serotonin transporter were investigated in vitro. Compounds 3–12(a and b) were obtained by nucleophilic substitution ...
    • Substituent Effect on the Photolability of 4-Aryl-1,4-Dihydropyridines 
      García, Cristóbal; Cabezas, Karina; Nonell, Santi; Núñez Vergara, Luis; Morales Valenzuela, Javier; Günther Sapunar, Germán; Pizarro Urzúa, Nancy Alejandra (The American Society of Photobiology, 2014)
      The electronic nature of substituents attached to the 4-aryl moiety of 1,4-dihydropyridines strongly affects the photophysical and photochemical behavior of these family of compounds. The presence of an electron donor ...
    • High hydrostatic pressure effect on chemical composition, color, phenolic acids and antioxidant capacity ... 
      Vega Gálvez, Antonio; López, Jéssica; Torres Ossandón, María José; Galotto, María José; Puente Díaz, Luis; Quispe Fuentes, Issis; Di Scala, Karina (Elsevier, 2014)
      The aim of this study was to evaluate the effects of high hydrostatic pressure (HHP) at 300, 400 and 500 MPa/1, 3 and 5 min on nutritional and antioxidant properties of Cape gooseberry pulp after immediate application ...
    • Structural re-arrangement in two hexanuclear CuII complexes: from a spin frustrated trigonal prism to a ... 
      Cañón Mancisidor, Walter Alberto; Gómez García, Carlos J.; Mínguez Espallargas, Guillermo; Vega, Andrés; Spodine Spiridonova, Evgenia; Venegas Yazigi, Diego; Coronado, Eugenio (The Royal Society of Chemistry, 2014)
      The addition of water to a chloroform solution of the Cu6 trigonal prism complex [Cu6(U6F)(U2OH)(U3OCH3)2(U2OCH3)2(3,5-Me2pz)6] (1) (3,5-Me2pz- = 3,5-dimethylpyrazolate) results in the formation of the Cu6 planar hexagonal ...
    • Synergic effect of two inorganic fillers on the mechanical and thermal Properties of hybrid polypropylene ... 
      Aguilar, Héctor; Yazdani-Pedram Zobeiri, Mehrdad; Toro, Patricio; Quijada Abarca, Juan; López Manchado, Miguel (2014)
      Inorganic fillers such as CaCO3 and clays are widely used as fillers to improve the mechanical and physical properties of polypropylene (PP). With the aim of improving simultaneously the stiffness and yield stress of PP, ...
    • Comparison of the total phenolic content, total anthocyanin content and antioxidant activity of polyphenol-rich ... 
      Fredes González, Carolina; Montenegro, Gloria; Zoffoli, Juan Pablo; Santander, Francisca; Robert Canales, Paz (Pontificia Universidad Católica de Chile, 2014)
      In the last 10 years, interest in research on polyphenol-rich fruit species has increased due to the potential health benefits of these species, mainly attributed to their high anthocyanin content and antioxidant activity. ...
    • Syntesis and crystalline structure of the exo-3,6-dimethyl-3,6-epoxi-1,2,3,6- tetrahydrophtlalimide and its ... 
      Vásquez Salfate, Rodrigo; Vetterlein, Claudia; Trujillo, Alexander; Escobar, Carlos; Araya Fuentes, Eyleen (2014)
      The molecular structure of the exo-3,6-dimethyl-3,6-epoxi-1,2,3,6-tetrahydrophthalimide (1), determined by X-ray diffraction analysis, as well as, its complete spectroscopic characterization and the synthesis and complete ...
    • GLP-1 promotes mitochondrial metabolism in vascular smooth muscle cells by enhancing endoplasmic ... 
      Morales, Pablo E.; Torres, Gloria; Sotomayor Torres, Cristian; Peña Oyarzún, Daniel; Rivera Mejías, Pablo; Paredes, Felipe; Chiong Lay, Mario (Elsevier, 2014)
      Incretin GLP-1 has important metabolic effects on several tissues, mainly through the regulation of glucose uptake and usage. One mechanism for increasing cell metabolism is modulating endoplasmic reticulum (ER)–mitochondria ...
    • Stress and the Reproductive Axis 
      Toufexis, D.; Rivarola, M. A.; Lara Peñaloza, Hernán; Viau, V. (British Society for Neuroendocrinology, 2014)
      There exists a reciprocal relationship between the hypothalamic-pituitary-adrenal (HPA) and the hypothalamic-pituitary-gonadal (HPG) axes, wherein the activation of one affects the function of the other and vice versa. ...
    • Spliced X-Box Binding Protein 1 Couples the Unfolded Protein Response to Hexosamine Biosynthetic Pathway 
      Wang, Zhao V.; Deng, Yingfeng; Gao, Ningguo; Pedrozo Cibils, Zully; Li, Dan L.; Morales, Cyndi R.; Criollo Céspedes, Alfredo; Luo, Xiang; Tan, Wei; Jiang, Nan; Lehrman, Mark A.; Rothermel, Beverly A.; Lee, Ann Hwee; Lavandero González, Sergio; Mammen, Pradeep P .A.; Ferdous, Anwarul; Gillette, Thomas G.; Scherer, Philipp E.; Hill, Joseph A. (Elsevier, 2014-03-13)
      The hexosamine biosynthetic pathway (HBP) generates uridine diphosphate N-acetylglucosamine (UDP-GlcNAc) for glycan synthesis and O-linked GlcNAc (O-GlcNAc) protein modifications. Despite the established role of the ...
    • Spectral and Kinetic Properties of Radical Cations Derived from Oxoisoaporphines: Relevance to Electron-Transfer ... 
      Fuente Urrutia, Julio de la; Kciuk, Gabriel; Aliaga Silva, Christian Marcelo; Bobrowski, Krzysztof (American Chemical Society, 2014)
      The thermally induced intermolecular electron transfer reaction in acetonitrile between the tetracyanoethylene (TCNE), a [pi]-electron acceptor with a large electron affinity, and six oxoisoaporphines (2,3-dihydro-7H-d ...
    • Enfermedad de chagas, biotransformación de xenobióticos por el trypanosama cruzi 
      Morello Casté, Antonio; Letelier, María Eugenia; Aldunate, Jorge; Repetto Scaramelli, Yolanda (Universidad de Chile, 1987)
    • Rotating-disk sorptive extraction: effect of the rotation mode of the extraction device on mass transfer efficiency 
      Jachero, Lourdes; Ahumada Torres, Aída Inés de Lourdes; Richter Duk, Pablo (Springer-Verlag, 2014)
      The extraction device used in rotating-disk sorptive extraction consists of a Teflon disk in which a sorptive phase is fixed on one of its surfaces. Depending on the configuration, the rotation axis of the disk device ...
    • Effect of biosolid application to Mollisol Chilean soils on the bioavailability of heavy metals (Cu, Cr, ... 
      Ahumada Torres, Aída Inés de Lourdes; Sepúlveda, Karen; Fernández, Priscilla; Ascar Estay, María Loreto; Pedraza, Cristina; Richter Duk, Pablo; Brown, Sally (Springer, 2014)
      Purpose This study assessed the effect of biosolid application on the bioavailable fraction of some trace elements (Cu, Cr, Ni, and Zn) using a bioassay with sunflower (Helianthus annuus) and a chemical assay, diffusion ...
    • Dopamine in human follicular fluid is associated with cellular uptake and metabolism-dependent generation ... 
      Saller, Sabine; Kunz, L.; Berg, D.; Berg, U.; Lara Peñaloza, Hernán; Urra, J.; Hecht, S.; Pavlik, R.; Thaler, C.J.; Mayerhofer, A. (Oxford University Press, 2014)
      studyquestion: Is the neurotransmitter dopamine (DA) in the human ovary involved in the generation of reactive oxygen species (ROS)? summary answer: Human ovarian follicular fluid contains DA, which causes the generation ...
    • Defined Single-Gene and Multi-Gene Deletion Mutant Collections in Salmonella enterica sv Typhimurium 
      Porwollik, Steffen; Santiviago Cid, Carlos; Cheng, Pui; Long, Fred; Desai, Prerak; Fredlund, Jennifer; Srikumar, Shabarinath; Silva, Cecilia A.; Chu, Weiping; Chen, Xin; Canals, Rocío; Reynolds, M. Megan; Bogomolnaya, Lydia; Shields, Christine; Cui, Ping; Guo, Jinbai; Zheng, Yi; Endicott Yazdani, Tiana; Yang, Hee-Jeong; Maple, Aimee; Ragoza, Yury; Blondel, Carlos J.; Valenzuela, Camila; Andrews Polymenis, Helene; McClelland, Michael (PLOS One, 2014)
      We constructed two collections of targeted single gene deletion (SGD) mutants and two collections of targeted multi-gene deletion (MGD) mutants in Salmonella enterica sv Typhimurium 14028s. The SGD mutant collections ...