Now showing items 201-220 of 2801

    • Rivera Valdés, Maira; Hao, Yuxin; Maillard, Rodrigo A.; Báez Larach, Mauricio (Nature, 2020)
      Knots are remarkable topological features in nature. The presence of knots in crystallographic structures of proteins have stimulated considerable research to determine the kinetic and thermodynamic consequences of threading ...
    • Becerra Herrera, Mercedes; Miranda, Valentina; Richter Duk, Pablo (Japan Soc Analytical Chemistry, 2020)
      An analytical methodology has been developed and validated for the purpose of identifying and quantifying four parabens (methylparaben, ethylparaben, propylparaben and n-butylparaben) in water samples. The combination of ...
    • Díaz Vegas, Alexis; Sánchez Aguilera, Pablo; Krycer, James R; Morales, Pablo E.; Monsalves Álvarez, Matías; Cifuentes Koster, Mariana; Rothermel, Beverly A.; Lavandero González, Sergio (Endocrine Society, 2020)
      Mitochondrial damage is implicated as a major contributing factor for a number of noncommunicable chronic diseases such as cardiovascular diseases, cancer, obesity, and insulin resistance/type 2 diabetes. Here, we discuss ...
    • Quaglio, Deborah; Corradi, Silvia; Erazo Giuffra, Silvia; Vergine, Valeria; Berardozzi, Simone; Sciubba, Fabio; Cappiello, Floriana; Crestoni, María Elisa; Ascenzioni, Fiorentina; Imperi, Francesco; Delle Monache, Franco; Mori, Mattia; Loffredo, Maria Rosa; Ghirga, Francesca; Casciaro, Bruno; Botta, Bruno; Mangoni, Maria Luisa (American Chemical Society, 2020)
      Novel diterpenoids were isolated from the extracts of Fabiana densa var. ramulosa and found to display a selective activity against Gram-positive bacterial strains with negligible cytotoxicity toward human keratinocytes. ...
    • Arriagada, Francisco; Ugarte Núñez, Catalina; Günther Sapunar, Germán; Larraín Barth, María Angélica; Guarnizo Herrero, Víctor; Nonell, Santi; Morales Valenzuela, Javier (MDPI, 2020)
      The incorporation of pigments and natural polyphenols into inorganic matrices, resulting in a hybrid material that improves the resistance and chemical stability of the pigments and the antioxidant capacity of the materials, ...
    • Jara Guajardo, Pedro; Cabrera, Pablo; Celis, Freddy; Soler Jauma, Mónica; Berlanga Mora, Isadora; Parra Muñoz, Nicole; Acosta, Gerardo; Albericio, Fernando; Guzmán, Fanny; Campos, Marcelo; Álvarez, Alejandra; Morales Zavala, Francisco; Kogan, Marcelo J. (MDPI, 2020)
      The early detection of the amyloid beta peptide aggregates involved in Alzheimer's disease is crucial to test new potential treatments. In this research, we improved the detection of amyloid beta peptide aggregates in vitro ...
    • Carmona, Danilo J.; Jaque-Olmedo, Pablo; Vöhringer Martínez, Esteban (Springer, 2020)
      Peroxides play a central role in many chemical and biological processes such as the Fenton reaction. The relevance of these compounds lies in the low stability of the O-O bond which upon dissociation results in radical ...
    • Cabrera Barjas, Gustavo; Quezada, Adriana; Bernardo, Yamilé; Moncada, Mauricio; Zúñiga, Elisa; Wilkens, Marcela; Giordano, Ady; Nesic, Aleksandra; Delgado, Nacarid (Springer, 2020)
      Murta (Ugni molinae Turcz) is an endemic Chilean specie mostly used in medical, cosmetic, and food industries. However, during the industrial processing of murta fruits, the biomass containing the seeds is discarded as an ...
    • Fuentealba Castro, Pablo; Olea Azar, Claudio; Aguilar Bolados, H.; Audebrand, N.; Santana, R. C. de; Doerenkamp, C.; Eckert, H.; Magon, C. J.; Spodine Spiridonova, Evgenia (Royal Society of Chemistry, 2020)
      Four bimetallic phases of the thiophosphate family have been synthesized by the cationic exchange reaction using a freshly prepared K0.5Cd0.75PS3 precursor phase and methanolic solutions of nitrates of the divalent cations ...
    • Ferdous, Anwarul; Wang, Zhao V.; Luo, Yuxuan; Li, Dan L.; Luo, Xiang; Schiattarella, Gabriele G.; Altamirano, Francisco; May, Herman I.; Battiprolu, Pavan K.; Nguyen, Annie; Rothermel, Beverly A.; Lavandero González, Sergio; Gillette, Thomas G.; Hill, Joseph A. (Nature, 2020)
      Forkhead box O (FoxO) proteins and thyroid hormone (TH) have well established roles in cardiovascular morphogenesis and remodeling. However, specific role(s) of individual FoxO family members in stress-induced growth and ...
    • Peña Ahumada, Bárbara; Saldarriaga Córdoba, Mónica; Kardailsky, Olga; Moncada, Ximena; Moraga Vergara, Mauricio; Matisoo Smith, Elizabeth; Seelenfreund, Daniela; Seelenfreund, Andrea (Public Library Science, 2020)
      Humans introduced paper mulberry (Broussonetia papyrifera) from Taiwan into the Pacific over 5000 years ago as a fiber source to make barkcloth textiles that were, and still are, important cultural artifacts throughout the ...
    • Mallco, Abdiel; Portillo, Carlos; Kogan, Marcelo J.; Galleguillos, Felipe; Fernández, Ángel G. (MDPI, 2020)
      Featured Application: monitoring the effect of molten salt corrosion on materials used in solar thermal plants by means of electrochemical tests.
    • Araujo Garrido, Juan Luis; Baisón Olmo, Fernando; Bernal Bayard, Joaquín; Romero, Francisco; Ramos Morales, Francisco (MDPI, 2020)
      Salmonella enterica serovar Typhimurium is a human and animal pathogen that uses type III secretion system effectors to manipulate the host cell and fulfill infection. SseK1 is a Salmonella effector with glycosyltransferase ...
    • Arriagada, Francisco; Gunther Sapunar, Germán; Morales Valenzuela, Javier (MDPI, 2020)
      Nanosystems used in pharmaceutical formulations have shown promising results in enhancing the administration of drugs of difficult formulations. In particular, porous silica nanoparticles have demonstrated excellent ...
    • Bravo Sagua, Roberto; Parra Ortiz, Valentina; Muñoz Córdova, Felipe; Sánchez Aguilera, Pablo; Garrido, Valeria; Contreras Ferrat, Ariel; Chiong Lay, Mario; Lavandero González, Sergio (Elsevier, 2020)
      The sarco/endoplasmic reticulum is an extensive, dynamic and heterogeneous membranous network that fulfills multiple homeostatic functions. Among them, it compartmentalizes, stores and releases calcium within the intracellular ...
    • Jara Moreno, Daniela; Riveros Salvatierra, Ana L.; Barriga G., Andrés; Kogan, Marcelo J.; Delporte Vergara, Carla (Bentham Science Publishers, 2020)
      The beta-amyloid peptide (1-42) is a molecule capable of aggregating into neurotoxic structures that have been implicated as potential etiological factors of Alzheimer's Disease. The aim of this study was to evaluate the ...
    • Ocaranza, María Paz; Valderas, Patricio; Moya, Jackeline; Gabrielli, Luigi; Godoy, Iván; Córdava, Samuel; Mac Nab, Paul; García Nannig, Lorena; Farías, Luis; Jalil, Jorge E. (BMC, 2020)
      BackgroundThe intracellular ROCK signaling pathway is an important modulator of blood pressure and of cardiovascular and renal remodeling when Rho-kinase activity is increased. Besides, in preclinical models of diabetes, ...
    • Nocetti, Diego; Núñez, Hipólito; Puente Díaz, Luis; Espinosa Escalona, Alejandra; Romero, Fernando (Wiley, 2020)
      Goldenberry is a wild fruit that has been widely used for centuries, mainly in folk medicine. Most studies of goldenberry have focused on the fruit, but new research has studied its byproducts, which were considered to ...
    • Robles Planells, Claudia; Sánchez-Guerrero, Giselle; Barrera Ávalos, Carlos; Matiacevich, Silvia; Rojo, Leonel E.; Pavéz, Jorge; Salas Huenuleo, Edison; Kogan, Marcelo J.; Escobar Álvarez, Alejandro; Milla, Luis A.; Fernández, Ricardo; Imarai, Mónica; Spencer, Eugenio; Huidobro Toro, Juan Pablo; Acuña Castillo, Claudio (Hindawi, 2020)
      Oncolytic virus therapy has been tested against cancer in preclinical models and clinical assays. Current evidence shows that viruses induce cytopathic effects associated with fusogenic protein-mediated syncytium formation ...
    • Cortés, Lionel; Pérez Won, Mario; Lemus Mondaca, Roberto; Giovagnoli Vicuña, Claudia; Uribe, Elsa (Wiley, 2020)
      Vinasse (pisco distillation waste) is a promising feedstock for developing new high value-added bioproducts because it is supporting sustainable production as an agroindustrial by-product. The aims of this study were to ...