Antibacterial, kinetics and bacteriolytic properties of silver(I) pyridinedicarboxylate compounds
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2014Metadata
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Azócar, M. Ignacio
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Antibacterial, kinetics and bacteriolytic properties of silver(I) pyridinedicarboxylate compounds
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Abstract
Antibacterial properties of silver(I)-pyridinedicarboxylate compounds (with Pyridine-2,3-dicarboxylic(Lutidinic
acid), pyridine-2,4-dicarboxylic (Quinolinic acid) and pyridine-2,5-dicarboxylic (Isocinchomeronic acid)) were
studied against Escherichia coli, Listeria monocytogenes (ISP-65-08), Salmonella typhi and Staphylococcus aureus
(ATCC 25923) using kinetics of grown inhibition, viability assays, minimuminhibitory concentration and optical
microscopy. The 3 silver compounds were tested toward UV-radiation in order to characterize their light insensitivity
for potential medical devices: UV-radiation curable polymers. Photophysical measurements show
remarkable differences toward UV-radiation, which were explained based on their polymeric structures with
multiple nature bonds between pyridinedicarboxylic ligands and Ag(I) centers. We found a bacteriolytic effect
and differences in the antibacterial efficiency depending on the structure of the complexes and the nature of
Ag\X (X = oxygen and nitrogen) bonds: AgQuinol N AgLutidin N AgIsocinchom.
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Patrocinador
This work was supported by FONDECYT (Grant Nos 11080133 and
1100537), CONICYT (Grant: 79090024) FONDAP 15130011 and DICYT
(No 021340AG).
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URI: https://repositorio.uchile.cl/handle/2250/121885
DOI: DOI: 10.1016/j.msec.2014.01.033
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Materials Science and Engineering C 37 (2014) 356–362
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