Preventing the recovery of extinguished ethanol tolerance
Author
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González, Valeria V.
Author
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Navarro, Victor
Author
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Míguez Cavieres, Gonzalo
Author
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Betancourt, Ronald
Author
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Laborda Rojas, Mario
Admission date
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2016-07-01T19:59:35Z
Available date
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2016-07-01T19:59:35Z
Publication date
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2016
Cita de ítem
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Behavioural Processes 124 (2016) 141–148
en_US
Identifier
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DOI: 10.1016/j.beproc.2016.01.004
Identifier
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https://repositorio.uchile.cl/handle/2250/139383
General note
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Artículo de publicación ISI
en_US
Abstract
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There is substantial evidence that drug-paired cues become associated with drug effects. From a Pavlovian perspective, these cues act as conditioned stimuli and elicit conditioned compensatory responses that contribute to drug tolerance. Here we report two experiments with rats in which we studied the extinction of the associative tolerance to the ataxic effect of ethanol. Experiment 1 evaluated whether changes in the temporal and physical contexts after extinction training provoke recovery of the extinguished tolerance. The results showed successful extinction, spontaneous recovery and renewal of the extinguished tolerance, but no summation of renewal and spontaneous recovery. Experiment 2 evaluated whether using massive extinction trials and delivering extinction in multiple contexts attenuates the renewal effect. The results showed that both manipulations reduced renewal of the extinguished tolerance to the ataxic effect of ethanol; however, these manipulations used in combination did not appear to be more effective in reducing recovery than each by itself. The present results may help guide further research that evaluates behavioral ploys to prevent the recovery of extinguished responses.
en_US
Patrocinador
dc.description.sponsorship
Fondo Nacional de Desarrollo Cientifico y Tecnologico (Fondecyt), Programa de Atraccion e Insercion de Capital Humano Avanzado (PAI).