Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores
Author
dc.contributor.author
Yévenes, Ismael
Author
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Torres Zamanillo, Carmen
Author
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Palma Fluxá, Patricia
Author
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Gajardo Ramirez, Marta
Author
dc.contributor.author
Maass, Paula
Author
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Quintana, Renata
Admission date
dc.date.accessioned
2018-12-20T15:22:40Z
Available date
dc.date.available
2018-12-20T15:22:40Z
Publication date
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2014
Cita de ítem
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Revista Odonto Ciencia, Volumen 29, Issue 3, 2014, Pages 81-86.
Identifier
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19806523
Identifier
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01029460
Identifier
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10.15448/1980-6523.2014.2.13114
Identifier
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https://repositorio.uchile.cl/handle/2250/158960
Abstract
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Objectives: A medicated chewing gum is a solid, single-dose preparation intended to be chewed for a
certain period of time and deliver the drug. It may contain one or more than one active pharmaceutical
ingredient. Whithin this context, we formulated a medicated gum with three active pharmaceutical
ingredients: Camphor, p-chlorophenol and hydrogen peroxide, to be evaluated as therapeutic agents
in dental caries. The aim of this study was to compare the effects on salivary streptococcus mutans,
pH, buffer capacity and secretion rate of three medicated gums containing chlorophenol / hydrogen
peroxide, xylitol or chlorhexidine.
Methods: Double-blind, randomized crossover treatment in 24 subjects. The patients were randomized
and subjected to six different treatment sequences. The subjects used, 1 gum tablet three times a day
for 20 minutes, morning, noon and night. At the beginning and end of the three experimental phases
saliva samples were obtained for determining the pH, buffer capacity, salivary flow rate and quantitative
enumeration of S. mutans.
Results: The use of medicated gum with camphor/p-chlorophenol and hydrogen peroxide did not
modify the salivary chemical parameters measured, and not significantly reduced the number of S.
mutans, after 7 days. Chewing gums with chlorhexidine significantly reduced the quantitative counting
of S. mutans salivary and flow rate in a period of 7 days.
Conclusions: The use of medicated chewing gums based on camphor/p-chlorophenol and hydrogen
peroxide does not alter the chemical salivary parameters and does not significantly reduce the number
of S. mutans, after a use over a period of 7 days.
Effects of chlorophenol / hydrogen peroxide versus xylitol or chlorhexidine as chewing gum on salivary flow rate, pH, buffer capacity and salivary Streptococcus mutans scores