Major histocompatibility system as a risk factor for alcoholic liver disease El sistema mayor de histocompatibilidad como factor de riesgo de la enfermedad hepática alcohólica.
Author
dc.contributor.author
Llop Romero, Elena
Author
dc.contributor.author
Hirsch Birn, Sandra
Author
dc.contributor.author
Maza Cave, María Pía de la
Author
dc.contributor.author
Bunout Barnett, Daniel
Author
dc.contributor.author
Iturriaga,
Author
dc.contributor.author
Silva Silva, Laura
Author
dc.contributor.author
Ugarte,
Author
dc.contributor.author
Rothhammer Engel, Francisco
Admission date
dc.date.accessioned
2019-01-29T14:14:03Z
Available date
dc.date.available
2019-01-29T14:14:03Z
Publication date
dc.date.issued
1995
Cita de ítem
dc.identifier.citation
Revista médica de Chile, Volumen 123, Issue 6, 2018, Pages 687-693
Identifier
dc.identifier.issn
00349887
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/160307
Abstract
dc.description.abstract
Several associations between alleles of the major histocompatibility system and alcoholic liver disease have been described. However, these are weak and change from one population to another. The aim of this work was to search for a possible genetic risk factor for alcoholic liver disease among Chilean alcoholics. We studied blood groups, serum proteins and HLA antigens in 39 alcoholic cirrhotics, 104 asymptomatic alcoholics and 44 non alcoholic controls. Asymptomatic alcoholics were also subjected to a percutaneous liver biopsy that showed moderate to severe histological liver damage in 46 subjects (44%). No differences in the studied genetic markers, were found among the four groups. It is concluded that this study does not confirm previously reported associations between genetic markers and alcoholic liver disease.
Major histocompatibility system as a risk factor for alcoholic liver disease El sistema mayor de histocompatibilidad como factor de riesgo de la enfermedad hepática alcohólica.