Gastric mucosal interleukin-8 in children colonized by Helicobacter pylori Niveles de interleuquina-8 en biopsias gástricas de niños colonizados por Helicobacter pylori
Author
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Chávez C, Eduardo
Author
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Sarmiento Q, Fernando
Author
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López G, Marcelo
Author
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Kakarieka W, Elena
Author
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Vial P., María Teresa
Author
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Gotteland, Martín
Admission date
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2019-01-29T17:15:59Z
Available date
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2019-01-29T17:15:59Z
Publication date
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1998
Cita de ítem
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Revista Medica de Chile, Volumen 126, Issue 2, 2018, Pages 139-143
Identifier
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00349887
Identifier
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https://repositorio.uchile.cl/handle/2250/163377
Abstract
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Background: Helicobacter pylori produces a gastric mucosal inflammation characterized by neutrophil infiltration, due to the liberation of interleukin-8. Aim: To measure interleukin-8 levels in gastric mucosa samples from children colonized by H. pylori. Patients and methods: Thirty one children that required an upper gastrointestinal endoscopy for diagnostic purpose were studied. Antral biopsies were obtained for pathological study, H. pylori detection using CLO-test and interleukin-8 determination by ELISA. Results: Nine children were not infected with H. pylori. Of these, six had a pathologically normal gastric mucosa and three had a mild chronic gastritis. Twenty two children were infected by H. pylori and all had a chronic gastritis with activity signs in 13. Mucosal interleukin-8 was higher in infected than in non infected children (59.7 (range 6.1-379.7) and 15.8 (range 3.9-104.1) pg/mg respectively p=0.029). Colonized children with an active chronic gastritis had higher interle
Gastric mucosal interleukin-8 in children colonized by Helicobacter pylori Niveles de interleuquina-8 en biopsias gástricas de niños colonizados por Helicobacter pylori