Large contribution of human papillomavirus in vaginal neoplastic lesions: A worldwide study in 597 samples
Author
dc.contributor.author
Alemany, L.
Author
dc.contributor.author
Saunier, M.
Author
dc.contributor.author
Tinoco, L.
Author
dc.contributor.author
Quirós, B.
Author
dc.contributor.author
Alvarado Cabrero, I.
Author
dc.contributor.author
Alejo, M.
Author
dc.contributor.author
Joura, E. A.
Author
dc.contributor.author
Maldonado, P.
Author
dc.contributor.author
Klaustermeier, J.
Author
dc.contributor.author
Salmerón, J.
Author
dc.contributor.author
Bergeron, C.
Author
dc.contributor.author
Petry, K. U.
Author
dc.contributor.author
Guimerà, N.
Author
dc.contributor.author
Clavero, O.
Author
dc.contributor.author
Murillo, R.
Author
dc.contributor.author
Clavel, C.
Author
dc.contributor.author
Wain, V.
Author
dc.contributor.author
Geraets, D. T.
Author
dc.contributor.author
Jach, R.
Author
dc.contributor.author
Cross, P.
Author
dc.contributor.author
Carrilho, C.
Author
dc.contributor.author
Molina, C.
Author
dc.contributor.author
Shin, H. R.
Author
dc.contributor.author
Mandys, V.
Author
dc.contributor.author
Nowakowski, A. M.
Author
dc.contributor.author
Vidal, A.
Author
dc.contributor.author
Lombardi, L.
Author
dc.contributor.author
Kitchener, H.
Author
dc.contributor.author
Sica, A. R.
Author
dc.contributor.author
Magaña León, C.
Author
dc.contributor.author
Pawlita, M.
Author
dc.contributor.author
Quint, W.
Author
dc.contributor.author
Bravo, I. G.
Author
dc.contributor.author
Muñoz, N.
Author
dc.contributor.author
Sanjosé, S. de
Author
dc.contributor.author
Bosch, F. X.
Admission date
dc.date.accessioned
2019-03-15T16:08:53Z
Available date
dc.date.available
2019-03-15T16:08:53Z
Publication date
dc.date.issued
2014
Cita de ítem
dc.identifier.citation
European Journal of Cancer 50 (2014) 2846–2854
Identifier
dc.identifier.issn
18790852
Identifier
dc.identifier.issn
09598049
Identifier
dc.identifier.other
10.1016/j.ejca.2014.07.018
Identifier
dc.identifier.uri
https://repositorio.uchile.cl/handle/2250/166362
Abstract
dc.description.abstract
Aim: This work describes the human papillomavirus (HPV) prevalence and the HPV type distribution in a large series of vaginal intraepithelial neoplasia (VAIN) grades 2/3 and vaginal cancer worldwide.
Methods: We analysed 189 VAIN 2/3 and 408 invasive vaginal cancer cases collected from 31 countries from 1986 to 2011. After histopathological evaluation of sectioned formalin-fixed paraffin-embedded samples, HPV DNA detection and typing was performed using the SPF-10/DNA enzyme immunoassay (DEIA)/LiPA(25) system (version 1). A subset of 146 vaginal cancers was tested for p16(INK4a) expression, a cellular surrogate marker for HPV transformation. Prevalence ratios were estimated using multivariate Poisson regression with robust variance.
Results: HPV DNA was detected in 74% (95% confidence interval (CI): 70-78%) of invasive cancers and in 96% (95% CI: 92-98%) of VAIN 2/3. Among cancers, the highest detection rates were observed in warty-basaloid subtype of squamous cell carcinomas, and in younger ages. Concerning the type-specific distribution, HPV16 was the most frequently type detected in both precancerous and cancerous lesions (59%). p16(INK4a) overexpression was found in 87% of HPV DNA positive vaginal cancer cases.
Conclusions: HPV was identified in a large proportion of invasive vaginal cancers and in almost all VAIN 2/3. HPV16 was the most common type detected. A large impact in the reduction of the burden of vaginal neoplastic lesions is expected among vaccinated cohorts.