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Author | dc.contributor.author | Saba, Laura M. | |
Author | dc.contributor.author | Flink, Stephen C. | |
Author | dc.contributor.author | Vanderlinden, Lauren A. | |
Author | dc.contributor.author | Israel Jacard, Yedy | |
Author | dc.contributor.author | Tampier, Lutske | |
Author | dc.contributor.author | Colombo, Giancarlo | |
Author | dc.contributor.author | Kiianmaa, Kalervo | |
Author | dc.contributor.author | Bell, Richard L. | |
Author | dc.contributor.author | Printz, Morton P. | |
Author | dc.contributor.author | Flodman, Pamela | |
Author | dc.contributor.author | Koob, George | |
Author | dc.contributor.author | Richardson, Heather N. | |
Author | dc.contributor.author | Lombardo, Joseph | |
Author | dc.contributor.author | Hoffman, Paula L. | |
Author | dc.contributor.author | Tabakoff, | |
Admission date | dc.date.accessioned | 2019-03-18T11:53:33Z | |
Available date | dc.date.available | 2019-03-18T11:53:33Z | |
Publication date | dc.date.issued | 2015 | |
Cita de ítem | dc.identifier.citation | FEBS Journal, Volumen 282, Issue 18, 2018, Pages 3556-3578 | |
Identifier | dc.identifier.issn | 17424658 | |
Identifier | dc.identifier.issn | 1742464X | |
Identifier | dc.identifier.other | 10.1111/febs.13358 | |
Identifier | dc.identifier.uri | https://repositorio.uchile.cl/handle/2250/166657 | |
Abstract | dc.description.abstract | © 2015 FEBS. A quantitative genetic approach, which involves correlation of transcriptional networks with the phenotype in a recombinant inbred (RI) population and in selectively bred lines of rats, and determination of coinciding quantitative trait loci for gene expression and the trait of interest, has been applied in the present study. In this analysis, a novel approach was used that combined DNA-Seq data, data from brain exon array analysis of HXB/BXH RI rat strains and six pairs of rat lines selectively bred for high and low alcohol preference, and RNA-Seq data (including rat brain transcriptome reconstruction) to quantify transcript expression levels, generate co-expression modules and identify biological functions that contribute to the predisposition of consuming varying amounts of alcohol. A gene co-expression module was identified in the RI rat strains that contained both annotated and unannotated transcripts expressed in the brain, and was associated with alcohol consumption | |
Lenguage | dc.language.iso | en | |
Publisher | dc.publisher | Blackwell Publishing Ltd | |
Type of license | dc.rights | Attribution-NonCommercial-NoDerivs 3.0 Chile | |
Link to License | dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/cl/ | |
Source | dc.source | FEBS Journal | |
Keywords | dc.subject | alcohol consumption | |
Keywords | dc.subject | gene expression | |
Keywords | dc.subject | HXB RI rat strains | |
Keywords | dc.subject | neuroinflammation | |
Keywords | dc.subject | rat selected lines | |
Título | dc.title | The sequenced rat brain transcriptome - Its use in identifying networks predisposing alcohol consumption | |
Document type | dc.type | Artículo de revista | |
Cataloguer | uchile.catalogador | SCOPUS | |
Indexation | uchile.index | Artículo de publicación SCOPUS | |
uchile.cosecha | uchile.cosecha | SI | |
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