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Author dc.contributor.author Parada-Bustamante, A.
Author dc.contributor.author Molina, C.
Author dc.contributor.author Valencia, C.
Author dc.contributor.author Flórez, M.
Author dc.contributor.author Lardone, M. C.
Author dc.contributor.author Argandoña, F.
Author dc.contributor.author Piottante, A.
Author dc.contributor.author Ebensperguer, M.
Author dc.contributor.author Orihuela, P. A.
Author dc.contributor.author Castro, A.
Admission date dc.date.accessioned 2019-03-18T11:56:19Z
Available date dc.date.available 2019-03-18T11:56:19Z
Publication date dc.date.issued 2017
Cita de ítem dc.identifier.citation Andrology, Volumen 5, Issue 3, 2018, Pages 486-494
Identifier dc.identifier.issn 20472927
Identifier dc.identifier.issn 20472919
Identifier dc.identifier.other 10.1111/andr.12346
Identifier dc.identifier.uri https://repositorio.uchile.cl/handle/2250/167075
Abstract dc.description.abstract © 2017 American Society of Andrology and European Academy of Andrology Estradiol (E2) is normally metabolized to hydroxyestradiols and methoxyestradiols by CYP1A1, CYP1B1 and COMT. However, an altered production of these metabolites by a disturbed expression of these enzymes is associated with reproductive and non-reproductive pathologies. In vitro studies suggest that increased hydroxyestradiols and methoxyestradiols intratesticular generation is related to male infertility, but no studies have explored whether infertile men have a disturbed testicular expression of the enzymes that generate these E2 metabolites. The aim of this study was to assess CYP1A1, CYP1B1 and COMT testicular expression at mRNA and protein level in men with spermatogenic impairment. Seventeen men with primary spermatogenic failure (13 with Sertoli cell-only syndrome and four with maturation arrest) and nine controls with normal spermatogenesis were subjected to testicular biopsy. mRNA was quantified using real-
Lenguage dc.language.iso en
Publisher dc.publisher Blackwell Publishing Ltd
Type of license dc.rights Attribution-NonCommercial-NoDerivs 3.0 Chile
Link to License dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/cl/
Source dc.source Andrology
Keywords dc.subject azoospermia
Keywords dc.subject enzyme
Keywords dc.subject estrogens/oestrogens
Keywords dc.subject immunohistochemistry
Keywords dc.subject Sertoli cell
Keywords dc.subject spermatocytic arrest
Keywords dc.subject steroidogenic enzymes
Keywords dc.subject testicular biopsy
Keywords dc.subject testis
Título dc.title Disturbed testicular expression of the estrogen-metabolizing enzymes CYP1A1 and COMT in infertile men with primary spermatogenic failure: possible negative implications on Sertoli cells
Document type dc.type Artículo de revista
Cataloguer uchile.catalogador SCOPUS
Indexation uchile.index Artículo de publicación SCOPUS
uchile.cosecha uchile.cosecha SI
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