Circulating Arsenic is Associated with Long-Term Risk of Graft Failure in Kidney Transplant Recipients: A Prospective Cohort Study
Author
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Sotomayor, Camilo G.
Author
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Groothof, Dion
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Vodegel, Joppe J.
Author
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Gacitúa, Tomás A.
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Gomes Neto, António W.
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Osté, Maryse C. J.
Author
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Pol, Robert A.
Author
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Ferreccio, Catterina
Author
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Berger, Stefan P.
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Chong, Guillermo
Author
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Slart, Riemer H. J. A.
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Rodrigo Salinas, Ramón
Author
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Navis, Gerjan J.
Author
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Touw, Daan J.
Author
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Bakker, Stephan J. L.
Admission date
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2020-04-15T21:08:50Z
Available date
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2020-04-15T21:08:50Z
Publication date
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2020
Cita de ítem
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J. Clin. Med. 2020, 9, 417
es_ES
Identifier
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10.3390/jcm9020417
Identifier
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https://repositorio.uchile.cl/handle/2250/173892
Abstract
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Arsenic is toxic to many organ systems, the kidney being the most sensitive target organ. We aimed to investigate whether, in kidney transplant recipients (KTRs), the nephrotoxic exposure to arsenic could represent an overlooked hazard for graft survival. We performed a prospective cohort study of 665 KTRs with a functional graft >= 1 year, recruited in a university setting (20082011), in The Netherlands. Plasma arsenic was measured by ICP-MS, and dietary intake was comprehensively assessed using a validated 177-item food-frequency questionnaire. The endpoint graft failure was defined as restart of dialysis or re-transplantation. Median arsenic concentration was 1.26 (IQR, 1.042.04) mu g/L. In backwards linear regression analyses we found that fish consumption (std beta = 0.26; p < 0.001) was the major independent determinant of plasma arsenic. During 5 years of follow-up, 72 KTRs developed graft failure. In Cox proportional-hazards regression analyses, we found that arsenic was associated with increased risk of graft failure (HR 1.80; 95% CI 1.28-2.53; p = 0.001). This association remained materially unaltered after adjustment for donor and recipient characteristics, immunosuppressive therapy, eGFR, primary renal disease, and proteinuria. In conclusion, in KTRs, plasma arsenic is independently associated with increased risk of late graft failure.
es_ES
Patrocinador
dc.description.sponsorship
Top Institute Food and Nutrition of the Netherlands
A-1003
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
F 72190118