Neurological Complications Associated with the Blood-Brain Barrier Damage Induced by the Inflammatory Response During SARS-CoV-2 Infection
Author
dc.contributor.author
Alquisiras Burgos, Iván
Author
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Peralta Arrieta, Irlanda
Author
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Alonso-Palomares, Luis
Author
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Zacapala Gómez, Ana Elvira
Author
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Salmerón Bárcenas, Eric Genaro
Author
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Aguilera, Penélope
Admission date
dc.date.accessioned
2021-01-13T22:17:44Z
Available date
dc.date.available
2021-01-13T22:17:44Z
Publication date
dc.date.issued
2020
Cita de ítem
dc.identifier.citation
Molecular Neurobiology Sep 2020
es_ES
Identifier
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10.1007/s12035-020-02134-7
Identifier
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https://repositorio.uchile.cl/handle/2250/178248
Abstract
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The main discussion above of the novel pathogenic severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has focusedon the immediate risks and impact on the respiratory system; however, the effects induced to the central nervous system are currently unknown. Some authors have suggested that SARS-CoV-2 infection can dramatically affect brain function and exacerbate neurodegenerative diseases in patients, but the mechanisms have not been entirely described. In this review, we gather information from past and actual studies on coronaviruses that informed neurological dysfunction and brain damage. Then, we analyzed and described the possible mechanisms causative of brain injury after SARS-CoV-2 infection. We proposed that potential routes of SARS-CoV-2 neuro-invasion are determinant factors in the process. We considered that the hematogenous route of infection can directly affect the brain microvascular endothelium cells that integrate the blood-brain barrier and be fundamental in initiation of brain damage. Additionally, activation of the inflammatory response against the infection represents a critical step on injury induction of the brain tissue. Consequently, the virus' ability to infect brain cells and induce the inflammatory response can promote or increase the risk to acquire central nervous system diseases. Here, we contribute to the understanding of the neurological conditions found in patients with SARS-CoV-2 infection and its association with the blood-brain barrier integrity.
es_ES
Patrocinador
dc.description.sponsorship
Consejo Nacional de Ciencia y Tecnología (CONACyT)
413994
Mexico City
SECTEI/138/2019