Moderate Aerobic Exercise Training Prevents the Augmented Hepatic Glucocorticoid Response Induced by High-Fat Diet in Mice
Author
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Dassonvalle, Jonatan
Author
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Díaz Castro, Francisco
Author
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Donoso Barraza, Camila
Author
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Sepúlveda, Carlos
Author
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Pino de la Fuente, Francisco
Author
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Pino, Pamela
Author
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Espinosa Escalona, Berta
Author
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Chiong Lay, Mario
Author
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Llanos Silva, Miguel
Author
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Troncoso Cotal, Rodrigo
Admission date
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2021-04-09T17:20:01Z
Available date
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2021-04-09T17:20:01Z
Publication date
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2020
Cita de ítem
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Int. J. Mol. Sci. 2020, 21, 7582
es_ES
Identifier
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10.3390/ijms21207582
Identifier
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https://repositorio.uchile.cl/handle/2250/179039
Abstract
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Glucocorticoids (GCs) are critical regulators of energy balance. Their deregulation is associated with the development of obesity and metabolic syndrome. However, it is not understood if obesity alters the tissue glucocorticoid receptor (GR) response, and moreover whether a moderate aerobic exercise prevents the alteration in GR response induced by obesity. Methods: To evaluate the GR response in obese mice, we fed C57BL6J mice with a high-fat diet (HFD) for 12 weeks. Before mice were sacrificed, we injected them with dexamethasone. To assess the exercise role in GR response, we fed mice an HFD and subjected them to moderate aerobic exercise three times a week. Results: We found that mice fed a high-fat diet for 12 weeks developed hepatic GC hypersensitivity without changes in the gastrocnemius or epididymal fat GR response. Therefore, moderate aerobic exercise improved glucose tolerance, increased the corticosterone plasma levels, and prevented hepatic GR hypersensitivity with an increase in epididymal fat GR response. Conclusion: Collectively, our results suggest that mice with HFD-induced obesity develop hepatic GR sensitivity, which could enhance the metabolic effects of HFD in the liver. Moreover, exercise was found to be a feasible non-pharmacological strategy to prevent the deregulation of GR response in obesity.
es_ES
Patrocinador
dc.description.sponsorship
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT
1191078
1180157
1181798
FONDAP
15130011