The Unfolded protein response in immune cells as an emerging regulator of neuroinflammation
Author
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Fernández Quezada, Dominique
Author
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Geisse Anguita, Antonia
Author
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Bernales Schnettler, José Ignacio
Author
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Lira, Alonso
Author
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Osorio Olivares, Fabiola
Admission date
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2021-08-24T12:28:34Z
Available date
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2021-08-24T12:28:34Z
Publication date
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2021
Cita de ítem
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Front. Aging Neurosci. 13:682633
es_ES
Identifier
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10.3389/fnagi.2021.682633
Identifier
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https://repositorio.uchile.cl/handle/2250/181448
Abstract
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Immune surveillance is an essential process that safeguards the homeostasis of a healthy brain. Among the increasing diversity of immune cells present in the central nervous system (CNS), microglia have emerged as a prominent leukocyte subset with key roles in the support of brain function and in the control of neuroinflammation. In fact, impaired microglial function is associated with the development of neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD). Interestingly, these pathologies are also typified by protein aggregation and proteostasis dysfunction at the level of the endoplasmic reticulum (ER). These processes trigger activation of the unfolded protein response (UPR), which is a conserved signaling network that maintains the fidelity of the cellular proteome. Remarkably, beyond its role in protein folding, the UPR has also emerged as a key regulator of the development and function of immune cells. However, despite this evidence, the contribution of the UPR to immune cell homeostasis, immune surveillance, and neuro-inflammatory processes remains largely unexplored. In this review, we discuss the potential contribution of the UPR in brain-associated immune cells in the context of neurodegenerative diseases.
es_ES
Patrocinador
dc.description.sponsorship
Howard Hughes Medical Institute 55008744
Comision Nacional de Investigacion Cientifica y Tecnologica (CONICYT)
CONICYT FONDECYT 1200793
ECOS-CONICYT grant ECOS180052